Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 9/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SLC29A1 | Q99808 | 2/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | KCNH3 | Q9ULD8 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.33 |
| ▸ | LATS1 | O95835 | 1/20 | 0.33 |
| ▸ | LATS2 | Q9NRM7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6168023 | 0.98 | KDM4E (0.40) | TLR8KDM4EALDH1A1HPGDSLC29A1 | |
| SCHEMBL6168059 | 0.79 | TLR8 (0.46) | TLR8KDM4EALDH1A1HPGDSLC29A1 | |
| SCHEMBL6204833 | 0.76 | CCR4 (0.42) | TLR8KDM4EALDH1A1HPGDSLC29A1 | |
| SCHEMBL4628918 | 0.70 | TLR8 (0.49) | TLR8SLC29A1TLR7 | |
| SCHEMBL6166426 | 0.70 | NPSR1 (0.39) | TLR8KDM4EALDH1A1HPGDSLC29A1 | |
| SCHEMBL6166433 | 0.69 | S1PR2 (0.41) | TLR8KDM4EALDH1A1HPGDSLC29A1 | |
| SCHEMBL6203304 | 0.68 | UTS2R (0.44) | TLR8KDM4ESLC29A1TLR7NPSR1 | |
| SCHEMBL10485739 | 0.64 | KCNH3 (0.50) | TLR8SLC29A1NPSR1KCNH3KMT2A | |
| SCHEMBL514975 | 0.64 | KCNH3 (0.63) | ALDH1A1SLC29A1NPSR1KCNH3KMT2A | |
| SCHEMBL14441528 | 0.62 | KMT2A (0.67) | SLC29A1NPSR1KCNH3KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1499599-A1 | SUBSTITUTED PYRAZINE DERIVATIVES | Pharmacia & Upjohn Company LLC (US) | 2005-01-26 | — | — | EP | disclosed |
| WO-2003091225-A1 | SUBSTITUTED PYRAZINE DERIVATIVES | PHARMACIA & UPJOHN COMPANY (US) | 2003-11-06 | — | — | WO | disclosed |