Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR2 | O95136 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.37 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.36 |
| ▸ | LATS1 | O95835 | 1/20 | 0.36 |
| ▸ | LATS2 | Q9NRM7 | 1/20 | 0.36 |
| ▸ | GBA1 | P04062 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
| ▸ | DNM2 | P50570 | 5/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.36 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.35 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.35 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.35 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6166426 | 0.98 | NPSR1 (0.39) | S1PR2LMNASMN1; SMN2NPSR1KMT2A | |
| SCHEMBL6203304 | 0.75 | UTS2R (0.44) | S1PR2LMNASMN1; SMN2NPSR1TLR8 | |
| SCHEMBL6166420 | 0.73 | PCSK9 (0.31) | — | |
| SCHEMBL6204833 | 0.72 | CCR4 (0.42) | S1PR2LMNASMN1; SMN2NPSR1TLR8 | |
| SCHEMBL6168023 | 0.71 | KDM4E (0.40) | S1PR2LMNASMN1; SMN2NPSR1KMT2A | |
| SCHEMBL6166430 | 0.70 | CRHR1 (0.38) | TLR8TLR7CYP2D6 | |
| SCHEMBL6165652 | 0.69 | TLR8 (0.41) | S1PR2LMNASMN1; SMN2NPSR1KMT2A | |
| SCHEMBL6168059 | 0.69 | TLR8 (0.46) | S1PR2LMNASMN1; SMN2NPSR1KMT2A | |
| SCHEMBL6166421 | 0.69 | CRHR1 (0.49) | — | |
| SCHEMBL9774909 | 0.69 | SMN1; SMN2 (0.51) | S1PR2LMNASMN1; SMN2NPSR1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1499599-A1 | SUBSTITUTED PYRAZINE DERIVATIVES | Pharmacia & Upjohn Company LLC (US) | 2005-01-26 | — | — | EP | disclosed |
| WO-2003091225-A1 | SUBSTITUTED PYRAZINE DERIVATIVES | PHARMACIA & UPJOHN COMPANY (US) | 2003-11-06 | — | — | WO | disclosed |