Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | PRKDC | P78527 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8371288 | 0.92 | PDE3B (0.39) | PDE3BPDE3AALDH1A1HSD17B10PRKDC | |
| SCHEMBL6158814 | 0.87 | PRKDC (0.37) | PDE3BPDE3AALDH1A1KDM4EPRKDC | |
| SCHEMBL6156255 | 0.83 | MEN1 (0.38) | PDE3BPDE3AALDH1A1HSD17B10KDM4E | |
| SCHEMBL6155845 | 0.77 | KMT2A (0.34) | ALDH1A1HSD17B10KDM4EHPGDHTT | |
| SCHEMBL6156254 | 0.77 | KDM4E (0.35) | ALDH1A1KDM4EHPGD | |
| SCHEMBL7784158 | 0.75 | ALDH1A1 (0.45) | ALDH1A1HSD17B10KDM4EMAPTHPGD | |
| SCHEMBL6942331 | 0.69 | LMNA (0.37) | KDM4E | |
| SCHEMBL7793422 | 0.69 | KDM4E (0.35) | ALDH1A1KDM4EHPGDSMN1; SMN2HTT | |
| SCHEMBL7605642 | 0.66 | ALDH1A1 (0.34) | ALDH1A1HSD17B10KDM4EMAPTHPGD | |
| SCHEMBL7792709 | 0.66 | POLB (0.30) | ALDH1A1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0894805-B1 | Ribose substituted aromatic derivatives, their preparation and use as medicaments | AVENTIS PHARMA SA (FR) | 2005-02-09 | — | — | EP | disclosed |
| EP-0894805-A1 | Ribose substituted aromatic derivatives, their preparation and use as medicaments | HOECHST MARION ROUSSEL (FR) | 1999-02-03 | — | — | EP | disclosed |