Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 4/20 | 0.34 |
| ▸ | CRHR1 | P34998 | 6/20 | 0.33 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.32 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.32 |
| ▸ | ACHE | P22303 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6166393 | 0.87 | CRHR1 (0.42) | KDM4EALDH1A1HPGDCRHR1STK17A | |
| SCHEMBL6169536 | 0.86 | CRHR1 (0.41) | KDM4EALDH1A1HPGDCRHR1TLR7 | |
| SCHEMBL6167259 | 0.84 | CRHR1 (0.44) | KDM4EALDH1A1HPGDCRHR1ACHE | |
| SCHEMBL6165056 | 0.84 | CRHR1 (0.43) | KDM4EALDH1A1HPGDCRHR1ACHE | |
| SCHEMBL6168821 | 0.81 | KDM4E (0.36) | KDM4EALDH1A1HPGDCRHR1TLR7 | |
| SCHEMBL6169750 | 0.81 | KDM4E (0.40) | KDM4EALDH1A1HPGDSTK17AACHE | |
| SCHEMBL6165790 | 0.79 | CRHR1 (0.53) | CRHR1 | |
| SCHEMBL6167908 | 0.77 | CRHR1 (0.34) | KDM4EALDH1A1HPGDCRHR1 | |
| SCHEMBL6166528 | 0.73 | CRHR1 (0.43) | KDM4EALDH1A1HPGDCRHR1ACHE | |
| SCHEMBL6166551 | 0.72 | KDM4E (0.43) | KDM4EALDH1A1HPGDCRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1499599-A1 | SUBSTITUTED PYRAZINE DERIVATIVES | Pharmacia & Upjohn Company LLC (US) | 2005-01-26 | — | — | EP | disclosed |
| WO-2003091225-A1 | SUBSTITUTED PYRAZINE DERIVATIVES | PHARMACIA & UPJOHN COMPANY (US) | 2003-11-06 | — | — | WO | disclosed |