SCHEMBL6165973

SCHEMBL6165973

NC(=O)N(O)CC1=Cc2cc(Cc3cccnc3)ccc2OC1

nearest known ligand 0.60

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 18/20 0.60
ALOX12 P18054 1/20 0.57
PTGS1 P23219 1/20 0.57
PTGS2 P35354 1/20 0.57
ALDH1A1 P00352 2/20 0.43
KMT2A Q03164 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9729637 0.85 ALOX5 (0.80) ALOX5ALOX12PTGS1PTGS2ALDH1A1
SCHEMBL6165724 0.79 ALDH1A1 (0.45) ALOX5ALDH1A1KMT2A
SCHEMBL9729583 0.75 ALOX5 (1.00) ALOX5ALOX12PTGS1PTGS2
SCHEMBL9729699 0.74 ALOX5 (1.00) ALOX5ALOX12PTGS1PTGS2
SCHEMBL6168726 0.74 ALDH1A1 (0.44) ALDH1A1KMT2A
SCHEMBL6008413 0.72 ALOX5 (1.00) ALOX5ALOX12PTGS1PTGS2
SCHEMBL9729661 0.72 ALOX5 (1.00) ALOX5ALOX12PTGS1PTGS2
SCHEMBL6166743 0.72 ALDH1A1 (0.42) ALDH1A1KMT2A
SCHEMBL9730189 0.69 ALOX5 (1.00) ALOX5ALOX12PTGS1PTGS2
SCHEMBL9729534 0.69 ALOX5 (0.74) ALOX5ALOX12PTGS1PTGS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1044974-B1 N-HYDROXYUREA DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME NIKKEN CHEMICALS CO LTD (JP) 2005-07-20 EP claimed
EP-1044974-A1 N-HYDROXYUREA DERIVATIVE AND MEDICINE CONTAINING THE SAME Nikken Chemicals Company, Limited (JP) 2000-10-18 EP claimed
JP-11209376-A None JP disclosed
EP-1044974-B1 N-HYDROXYUREA DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME NIKKEN CHEMICALS CO LTD (JP) 2005-07-20 EP disclosed
EP-1044974-B1 N-HYDROXYUREA DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME NIKKEN CHEMICALS CO LTD (JP) 2005-07-20 EP disclosed
EP-1044974-A4 N-HYDROXYUREA DERIVATIVE AND MEDICINE CONTAINING THE SAME NIKKEN CHEMICALS CO LTD (JP) 2003-01-22 EP disclosed
JP-2002020289-A PROSTAGLANDIN E2 PRODUCTION PROMOTER NIKKEN CHEM CO LTD 2002-01-23 JP disclosed
JP-2002020288-A LEUKOCYTIC INFILTRATION INHIBITOR NIKKEN CHEM CO LTD 2002-01-23 JP disclosed
US-6291482-B1 THROMBOXANE SYNTHASE INHIBITORY ANTI-INFLAMMATORY DRUG COMPRISING N-HYDROXY-N-(6-(3-PYRIDYMETHYL)-2H-1-BENZOPYRAN-3-YLMETHYL)URE A; ANTIALLERGIC, ANTIASTHMATIC NIKKEN CHEMICALS CO., LTD (JP) 2001-09-18 US disclosed
US-6291482-B1 THROMBOXANE SYNTHASE INHIBITORY ANTI-INFLAMMATORY DRUG COMPRISING N-HYDROXY-N-(6-(3-PYRIDYMETHYL)-2H-1-BENZOPYRAN-3-YLMETHYL)URE A; ANTIALLERGIC, ANTIASTHMATIC NIKKEN CHEMICALS CO., LTD (JP) 2001-09-18 US disclosed
EP-1044974-A1 N-HYDROXYUREA DERIVATIVE AND MEDICINE CONTAINING THE SAME Nikken Chemicals Company, Limited (JP) 2000-10-18 EP disclosed
EP-1044974-A1 N-HYDROXYUREA DERIVATIVE AND MEDICINE CONTAINING THE SAME Nikken Chemicals Company, Limited (JP) 2000-10-18 EP disclosed
JP-H11209376-A N-HYDROXYUREA DERIVATIVE AND PHARMACEUTICAL CONTAINING THE SAME NIKKEN CHEM CO LTD 1999-08-03 JP disclosed
WO-1999024426-A1 N-HYDROXYUREA DERIVATIVE AND MEDICINE CONTAINING THE SAME NIKKEN CHEMICALS CO., LTD. (JP) 1999-05-20 WO disclosed