Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 3/20 | 0.38 |
| ▸ | F2 | P00734 | 5/20 | 0.37 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.37 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.37 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.37 |
| ▸ | F10 | P00742 | 11/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.33 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6166090 | 0.93 | ALOX5AP (0.32) | IKBKBF2PRSS1PRSS2PRSS3 | |
| SCHEMBL7104633 | 0.79 | F10 (0.46) | F2PRSS1PRSS2PRSS3F10 | |
| SCHEMBL6164926 | 0.72 | F10 (0.51) | F2PRSS1PRSS2PRSS3F10 | |
| SCHEMBL25439559 | 0.66 | GAA (0.47) | IKBKB | |
| SCHEMBL6167430 | 0.65 | ALDH1A1 (0.37) | IKBKB | |
| SCHEMBL6303170 | 0.65 | MKNK1 (0.54) | F2PRSS1PRSS2PRSS3F10 | |
| SCHEMBL6162566 | 0.64 | F10 (0.50) | F2PRSS1PRSS2PRSS3F10 | |
| SCHEMBL28790250 | 0.62 | IKBKB (0.54) | IKBKB | |
| SCHEMBL5171111 | 0.62 | BAZ2B (0.50) | F2PRSS1PRSS2PRSS3F10 | |
| SCHEMBL3830209 | 0.61 | PTGS2 (0.48) | ALOX5APFEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1254136-A4 | FACTOR Xa INHIBITORS WITH ARYL-AMIDINES AND DERIVATIVES, AND PRODRUGS THEREOF | LG CHEM INVESTMENT LTD (KR) | 2005-06-01 | — | — | EP | disclosed |
| EP-1254136-A1 | FACTOR Xa INHIBITORS WITH ARYL-AMIDINES AND DERIVATIVES, AND PRODRUGS THEREOF | LG Chem Investment, Ltd. (KR) | 2002-11-06 | — | — | EP | disclosed |
| WO-2001055146-A1 | FACTOR Xa INHIBITORS WITH ARYL-AMIDINES AND DERIVATIVES, AND PRODRUGS THEREOF | LG CHEM INVESTMENT LTD. (KR) | 2001-08-02 | — | — | WO | disclosed |