Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 2/20 | 0.34 |
| ▸ | MMP7 | P09237 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 6/20 | 0.33 |
| ▸ | MMP13 | P45452 | 4/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | ADAM17 | P78536 | 6/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | MMP8 | P22894 | 1/20 | 0.32 |
| ▸ | CETP | P11597 | 1/20 | 0.31 |
| ▸ | P2RY12 | Q9H244 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5957537 | 1.00 | ACACB (0.34) | ACACBMMP7HCRTR2MMP13CYP3A4 | |
| SCHEMBL6201446 | 0.90 | MMP7 (0.35) | ACACBMMP7HCRTR2MMP13CYP3A4 | |
| SCHEMBL6201448 | 0.90 | MMP7 (0.35) | ACACBMMP7HCRTR2MMP13CYP3A4 | |
| SCHEMBL5957627 | 0.88 | MMP7 (0.33) | MMP7MMP13CYP3A4ADAM17MMP2 | |
| SCHEMBL5949327 | 0.85 | ADAM17 (0.34) | MMP7HCRTR2MMP13CYP3A4ADAM17 | |
| SCHEMBL5949570 | 0.84 | TMEM97 (0.38) | MMP7MMP13MMP2 | |
| SCHEMBL5957841 | 0.84 | CYP2C19 (0.41) | MMP13ADAM17MMP2 | |
| SCHEMBL5949405 | 0.83 | MMP13 (0.34) | MMP7HCRTR2MMP13CYP3A4ADAM17 | |
| SCHEMBL5949440 | 0.83 | TACR1 (0.37) | MMP7HCRTR2MMP13CYP3A4ADAM17 | |
| SCHEMBL5949382 | 0.81 | ADAM17 (0.46) | ADAM17MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1531821-A2 | SULPHONYLPIPERIDINE DERIVATIVES CONTAINING AN ALKENYL OR ALKYNYL MOIETY FOR USE AS MATRIX METALLOPROTEINASE INHIBITORS | Astrazeneca AB (SE) | 2005-05-25 | — | — | EP | disclosed |
| WO-2004006927-A2 | SULPHONYLPIPERIDINE DERIVATIVES CONTAINING AN ALKENYL OR ALKYNLY MOIETY FOR USE AS MATRIX METALLOPROTEINASE INHIBITORS | ASTRAZENECA AB (SE) | 2004-01-22 | — | — | WO | disclosed |