SCHEMBL6166304

SCHEMBL6166304

[c]1cccc2c(Cc3ccccn3)nccc12

nearest known ligand 0.44

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.44
L3MBTL1 Q9Y468 1/20 0.37
HRH3 Q9Y5N1 2/20 0.36
HRH4 Q9H3N8 1/20 0.36
HRH1 P35367 1/20 0.35
ALDH1A1 P00352 2/20 0.35
LMNA P02545 2/20 0.35
TAAR1 Q96RJ0 1/20 0.35
ALOX15 P16050 1/20 0.35
MAPT P10636 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
LIN28A Q9H9Z2 1/20 0.34
TDP1 Q9NUW8 1/20 0.34
FDPS P14324 2/20 0.33
PTPRA P18433 1/20 0.33
HTT P42858 1/20 0.33
NPC1 O15118 1/20 0.33
RAB9A P51151 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6164398 0.77 FLT1 (0.38)
SCHEMBL5659986 0.76 L3MBTL1 (0.40) TSHRL3MBTL1ALDH1A1LMNAMAPT
SCHEMBL6168574 0.74 GAA (0.39) HRH3HRH4ALDH1A1HTT
SCHEMBL668548 0.68 L3MBTL1 (0.44) TSHRL3MBTL1HRH3HRH4HRH1
SCHEMBL6166087 0.68 L3MBTL1 (0.44) TSHRL3MBTL1HRH3HRH4HRH1
SCHEMBL29830938 0.68 L3MBTL1 (0.59) TSHRL3MBTL1HRH3HRH4HRH1
SCHEMBL41191 0.68 L3MBTL1 (0.59) TSHRL3MBTL1HRH3HRH4HRH1
SCHEMBL5658693 0.68 NOS3 (0.50)
SCHEMBL6968370 0.66 PSMD14 (0.35)
SCHEMBL5660661 0.66 HTT (0.32) TSHRALDH1A1LMNAALOX15MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1417177-A4 ACYLSEMICARBAZIDES AS CYCLIN DEPENDENT KINASE INHIBITORS USEFUL AS ANTI-CANCER AND ANTI-PROLIFERATIVE AGENTS BRISTOL MYERS SQUIBB PHARMA CO (US) 2005-10-19 EP disclosed
EP-1417177-A2 ACYLSEMICARBAZIDES AS CYCLIN DEPENDENT KINASE INHIBITORS USEFUL AS ANTI-CANCER AND ANTI-PROLIFERATIVE AGENTS Bristol-Myers Squibb Pharma Company (US) 2004-05-12 EP disclosed
WO-2003007883-A2 ACYLSEMICARBAZIDES AS CYCLIN DEPENDENT KINASE INHIBITORS USEFUL AS ANTI-CANCER AND ANTI-PROLIFERATIVE AGENTS BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) 2003-01-30 WO disclosed
EP-1071668-A1 5-AMINOINDENO(1,2-C)PYRAZOL-4-ONES AS ANTI-CANCER AND ANTI-PROLIFERATIVE AGENTS Du Pont Pharmaceuticals Company (US) 2001-01-31 EP disclosed
WO-1999054308-A1 5-AMINOINDENO(1,2-C)PYRAZOL-4-ONES AS ANTI-CANCER AND ANTI-PROLIFERATIVE AGENTS DU PONT PHARMACEUTICALS COMPANY (US) 1999-10-28 WO disclosed