Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 18/20 | 0.78 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.56 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.55 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6771820 | 0.86 | OPRM1 (0.75) | OPRM1HSP90AB1OPRK1OPRD1 | |
| SCHEMBL6767112 | 0.86 | OPRM1 (0.58) | OPRM1HSP90AB1TP53 | |
| SCHEMBL6777174 | 0.86 | OPRM1 (0.58) | OPRM1HSP90AB1TP53 | |
| SCHEMBL6771516 | 0.86 | OPRM1 (0.58) | OPRM1HSP90AB1TP53 | |
| SCHEMBL6163702 | 0.85 | OPRM1 (0.62) | OPRM1HSP90AB1OPRK1OPRD1 | |
| SCHEMBL6166305 | 0.84 | OPRM1 (0.76) | OPRM1OPRK1OPRD1 | |
| SCHEMBL6770581 | 0.84 | ALDH1A1 (0.62) | OPRM1HSP90AB1TP53 | |
| SCHEMBL6769486 | 0.83 | OPRM1 (0.55) | OPRM1HSP90AB1TP53 | |
| SCHEMBL6164762 | 0.82 | OPRM1 (0.59) | OPRM1HSP90AB1OPRK1OPRD1 | |
| SCHEMBL6770366 | 0.81 | SRC (0.56) | OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6716856-B1 | CELL PROLIFERATIVE DISORDERS OR ALZHEIMER'S DISEASE; REDUCED TOXICITY; CDK/CYCLIN KINASE INHIBITORY ACTIVITY | PHARMACIA & TUBJOHN SPA (IT) | 2004-04-06 | — | — | US | disclosed |