Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 6/20 | 0.39 |
| ▸ | RAB9A | P51151 | 5/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | GCK | P35557 | 1/20 | 0.37 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.36 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.36 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2652100 | 0.81 | KCNH2 (0.53) | LMNAFFAR2KCNH2KMT2AMEN1 | |
| SCHEMBL2653133 | 0.80 | SLC6A3 (0.41) | LMNAKCNH2GCK | |
| SCHEMBL2652717 | 0.80 | KCNH2 (0.39) | LMNAKCNH2GCK | |
| SCHEMBL2651926 | 0.80 | KCNH2 (0.39) | LMNAKCNH2ALDH1A1GCK | |
| SCHEMBL2652192 | 0.69 | FFAR2 (0.46) | LMNAFFAR2KCNH2SMN1; SMN2ALDH1A1 | |
| SCHEMBL2652710 | 0.69 | LMNA (0.44) | LMNA | |
| SCHEMBL2652305 | 0.69 | SLC6A3 (0.54) | LMNA | |
| SCHEMBL2653474 | 0.69 | KCNH2 (0.56) | LMNAFFAR2KCNH2KMT2AMEN1 | |
| SCHEMBL2653272 | 0.67 | LMNA (0.43) | LMNA | |
| SCHEMBL2652746 | 0.67 | KCNH2 (0.44) | LMNAKCNH2ALDH1A1GCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1305301-B1 | ALPHA-ACYL AND ALPHA-HETEROATOM-SUBSTITUTED BENZENE ACETAMIDE GLUCOKINASE ACTIVATORS | HOFFMANN LA ROCHE (CH) | 2005-06-15 | — | — | EP | claimed |