SCHEMBL6166698

SCHEMBL6166698

COC(=O)c1nc(C(=O)CBr)cc(NC(C)=O)c1Cl

nearest known ligand 0.41

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.41
IAPP P10997 1/20 0.38
PGK1 P00558 1/20 0.35
NQO2 P16083 2/20 0.35
NPSR1 Q6W5P4 1/20 0.34
MAPT P10636 3/20 0.33
CYP1A2 P05177 1/20 0.33
SMN1; SMN2 Q16637 2/20 0.33
TDP1 Q9NUW8 1/20 0.33
KDM4E B2RXH2 1/20 0.32
LMNA P02545 1/20 0.32
GPR35 Q9HC97 1/20 0.32
MAPK8 P45983 1/20 0.32
CA1 P00915 1/20 0.32
CA2 P00918 1/20 0.32
CA9 Q16790 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20955429 0.83 ALDH1A1 (0.43) ALDH1A1IAPPPGK1NQO2NPSR1
SCHEMBL16776856 0.81 ALDH1A1 (0.42) ALDH1A1IAPPPGK1NQO2NPSR1
SCHEMBL32669001 0.79 ALDH1A1 (0.48) ALDH1A1IAPPPGK1NQO2NPSR1
SCHEMBL2338797 0.79 ALDH1A1 (0.48) ALDH1A1IAPPPGK1NQO2NPSR1
SCHEMBL6165559 0.79 SMN1; SMN2 (0.40) ALDH1A1IAPPPGK1NQO2NPSR1
SCHEMBL20727067 0.78 ALDH1A1 (0.47) ALDH1A1IAPPPGK1NPSR1MAPT
SCHEMBL16776819 0.78 ALDH1A1 (0.39) ALDH1A1IAPPPGK1NQO2NPSR1
SCHEMBL16029610 0.77 ALDH1A1 (0.46) ALDH1A1IAPPPGK1NQO2NPSR1
SCHEMBL16776848 0.77 ALDH1A1 (0.39) ALDH1A1IAPPPGK1NQO2NPSR1
SCHEMBL3329174 0.76 ALDH1A1 (0.36) ALDH1A1IAPPNQO2MAPTCYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1414814-B1 6-ARYL-4-AMINOPICOLINATES AND THEIR USE AS HERBICIDES DOW AGROSCIENCES LLC (US) 2005-02-02 EP disclosed
US-6784137-B2 SUCH AS 5,6-DICHLOROPYRIDINE-2-CARBOXYLIC ACID-N-OXIDE FOR PREEMERGENCE APPLICATION DOW AGROSCIENCES LLC 2004-08-31 US disclosed
EP-1414814-A1 6-ARYL-4-AMINOPICOLINATES AND THEIR USE AS HERBICIDES Dow Agrosciences LLC (US) 2004-05-06 EP disclosed
US-20030114311-A1 6-Aryl-4-aminopicolinates and their use as herbicides CORTEVA AGRISCIENCE LLC 2003-06-19 US disclosed
WO-2003011853-A1 6-ARYL-4-AMINOPICOLINATES AND THEIR USE AS HERBICIDES DOW AGROSCIENCES LLC (US) 2003-02-13 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030114311-A1 6-Aryl-4-aminopicolinates and their use as herbicides AADAC, DDT, AADAT ALDH1A1 713/4885IAPP 3469/4885PGK1 3890/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.