Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 4/20 | 0.36 |
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | HTR2C | P28335 | 2/20 | 0.36 |
| ▸ | HTR2B | P41595 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18498321 | 0.96 | KCNH2 (0.37) | PARP1HTR2AHTR2CHTR2BCHRNB2 | |
| SCHEMBL17401124 | 0.96 | KCNH2 (0.37) | PARP1HTR2AHTR2CHTR2BCHRNB2 | |
| SCHEMBL10177443 | 0.88 | CHRNB2 (0.39) | PARP1MEN1CYP2D6CYP2C19KMT2A | |
| SCHEMBL15105935 | 0.87 | CHRNB2 (0.38) | PARP1MEN1CYP2D6CYP2C19KMT2A | |
| SCHEMBL883089 | 0.87 | CHRNB2 (0.38) | PARP1MEN1CYP2D6CYP2C19KMT2A | |
| SCHEMBL882749 | 0.87 | CHRNB2 (0.38) | PARP1MEN1CYP2D6CYP2C19KMT2A | |
| SCHEMBL6166576 | 0.86 | NR1H4 (0.41) | PARP1MEN1CYP2D6CYP2C19KMT2A | |
| SCHEMBL1056603 | 0.86 | CYP2D6 (0.41) | PARP1MEN1CYP2D6CYP2C19KMT2A | |
| SCHEMBL12961554 | 0.86 | CYP2D6 (0.41) | PARP1MEN1CYP2D6CYP2C19KMT2A | |
| SCHEMBL2368242 | 0.84 | PARP1 (0.34) | PARP1HTR2AHTR2CHTR2BCHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1349850-B1 | SODIUM CHANNEL MODULATORS DERIVED FROM 2-PIPERIDYLIMIDAZOLES | SOD CONSEILS RECH APPLIC (FR) | 2005-09-07 | — | — | EP | claimed |
| CN-1214025-C | Sodium channel modulators derived from 2-piperidylimidazoles | SOD CONSEILS RECH APPLIC (FR) | 2005-08-10 | — | — | CN | claimed |
| CN-1483029-A | Sodium channel modulators derived from 2-piperidylimidazoles | ��ѧ�о���Ӧ����ѯ��˾ | 2004-03-17 | — | — | CN | claimed |
| EP-1349850-A1 | SODIUM CHANNEL MODULATORS DERIVED FROM 2-PIPERIDYLIMIDAZOLES | Société de Conseils de Recherches et d'Applications Scientifiques ( S.C.R.A.S.) (FR) | 2003-10-08 | — | — | EP | claimed |
| WO-2002053559-A1 | SODIUM CHANNEL MODULATORS DERIVED FROM 2-PIPERIDYLIMIDAZOLES | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 2002-07-11 | — | — | WO | claimed |
| EP-4045491-A1 | SUBSTITUTED AZACYLES AS TRMP8 MODULATORS | Givaudan SA (CH) | 2022-08-24 | — | — | EP | disclosed |
| CN-1214025-C | Sodium channel modulators derived from 2-piperidylimidazoles | SOD CONSEILS RECH APPLIC (FR) | 2005-08-10 | — | — | CN | disclosed |
| US-20040077640-A1 | Sodium channel modulators derived from 2-piperidylimidazoles | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 2004-04-22 | — | — | US | disclosed |
| CN-1483029-A | Sodium channel modulators derived from 2-piperidylimidazoles | ��ѧ�о���Ӧ����ѯ��˾ | 2004-03-17 | — | — | CN | disclosed |
| EP-1349850-A1 | SODIUM CHANNEL MODULATORS DERIVED FROM 2-PIPERIDYLIMIDAZOLES | Société de Conseils de Recherches et d'Applications Scientifiques ( S.C.R.A.S.) (FR) | 2003-10-08 | — | — | EP | disclosed |
| WO-2002053559-A1 | SODIUM CHANNEL MODULATORS DERIVED FROM 2-PIPERIDYLIMIDAZOLES | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 2002-07-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040077640-A1 | Sodium channel modulators derived from 2-piperidylimidazoles | KCNH1, HCN4, KCNH2 | PARP1 3515/4885HTR2A 1219/4885HTR2C 652/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.