Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.51 |
| ▸ | HTR1D | P28221 | 2/20 | 0.47 |
| ▸ | HTR1B | P28222 | 2/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | CTSL | P07711 | 1/20 | 0.42 |
| ▸ | CTSB | P07858 | 1/20 | 0.42 |
| ▸ | CTSK | P43235 | 1/20 | 0.42 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.41 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19617897 | 0.83 | TRPV6 (0.55) | TRPV6HTR1DHTR1BCTSLCTSB | |
| SCHEMBL19616936 | 0.83 | TRPV6 (0.55) | TRPV6HTR1DHTR1BCTSLCTSB | |
| SCHEMBL19947782 | 0.82 | TRPV6 (0.50) | TRPV6HTR1DHTR1BCTSLCTSB | |
| SCHEMBL19948638 | 0.82 | TRPV6 (0.50) | TRPV6HTR1DHTR1BCTSLCTSB | |
| SCHEMBL21908568 | 0.82 | TRPV6 (0.50) | TRPV6HTR1DHTR1BCTSLCTSB | |
| SCHEMBL14502963 | 0.79 | CHRNB2 (0.57) | — | |
| SCHEMBL22110284 | 0.79 | CHRNB2 (0.57) | — | |
| SCHEMBL4663279 | 0.79 | DPP4 (0.60) | TRPV6HTR1DHTR1B | |
| SCHEMBL6462811 | 0.79 | DPP4 (0.60) | TRPV6HTR1DHTR1B | |
| SCHEMBL22110450 | 0.79 | CHRM3 (0.49) | TRPV6CTSLCTSBCTSKSLC18A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1372692-A4 | ASYMMETRIC SYNTHESIS OF (S, S, R)-(-)-ACTINONIN AND ITS ANALOGS AND USES THEREFOR | SLOAN KETTERING INST CANCER (US) | 2005-10-26 | — | — | EP | disclosed |
| EP-1372692-A2 | ASYMMETRIC SYNTHESIS OF (S, S, R)-(-)-ACTINONIN AND ITS ANALOGS AND USES THEREFOR | Sloan Kettering Institute For Cancer Research (US) | 2004-01-02 | — | — | EP | disclosed |
| WO-2002074050-A2 | ASYMMETRIC SYNTHESIS OF (S, S, R)-(-)-ACTINONIN AND ITS ANALOGS AND USES THEREFOR | SLOAN KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2002-09-26 | — | — | WO | disclosed |