Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSC | P53634 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8607040 | 1.00 | CTSC (0.46) | CTSCALDH1A1TSHRHTR2CBACE1 | |
| SCHEMBL20745388 | 0.89 | CTSC (0.50) | CTSCALDH1A1TSHRHTR2CBACE1 | |
| SCHEMBL16407831 | 0.89 | CTSC (0.50) | CTSCALDH1A1TSHRHTR2CBACE1 | |
| SCHEMBL12480861 | 0.89 | CTSC (0.50) | CTSCALDH1A1TSHRHTR2CBACE1 | |
| SCHEMBL21964312 | 0.89 | CTSC (0.50) | CTSCALDH1A1TSHRHTR2CBACE1 | |
| SCHEMBL19388654 | 0.89 | CTSC (0.50) | CTSCALDH1A1TSHRHTR2CBACE1 | |
| Hydrochloric Acid SCHEMBL25201793 | 0.88 | TSHR (0.52) | CTSCALDH1A1TSHRHTR2CBACE1 | |
| Hydrochloric Acid SCHEMBL29820504 | 0.88 | TSHR (0.52) | CTSCALDH1A1TSHRHTR2CBACE1 | |
| SCHEMBL8602762 | 0.86 | ALDH1A1 (0.43) | CTSCALDH1A1TSHRHTR2CBACE1 | |
| SCHEMBL8604142 | 0.86 | ALDH1A1 (0.43) | CTSCALDH1A1TSHRHTR2CBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465891-A4 | INHIBITORS OF DIPEPTIDYL PEPTIDASE IV | GUILFORD PHARM INC (US) | 2005-08-17 | — | — | EP | disclosed |
| EP-1465891-A2 | INHIBITORS OF DIPEPTIDYL PEPTIDASE IV | GUILFORD PHARMACEUTICALS INC. (US) | 2004-10-13 | — | — | EP | disclosed |
| WO-2003057666-A2 | INHIBITORS OF DIPEPTIDYL PEPTIDASE IV | GUILFORD PHARMACEUTICALS (US) | 2003-07-17 | — | — | WO | disclosed |
| WO-2003057144-A2 | CHANGE INHIBITORS OF DIPEPTIDYL PEPTIDASE IV | GUILFORD PHARMACEUTICALS (US) | 2003-07-17 | — | — | WO | disclosed |