SCHEMBL6167162

SCHEMBL6167162

COc1ccc2[nH]cc(C3CCN(OC(=O)O)CC3)c2c1

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MTNR1A P48039 1/20 0.62
MTNR1B P49286 1/20 0.62
HTR1A P08908 7/20 0.54
SLC6A4 P31645 7/20 0.54
HSD11B1 P28845 2/20 0.53
HTR2A P28223 2/20 0.52
DRD2 P14416 1/20 0.52
HTR7 P34969 1/20 0.52
HTR6 P50406 1/20 0.52
CCR2 P41597 1/20 0.50
HTR2C P28335 1/20 0.50
HTR2B P41595 1/20 0.50
MAPT P10636 1/20 0.50
BLM P54132 1/20 0.50
NPSR1 Q6W5P4 1/20 0.50
CYP1A2 P05177 1/20 0.49
CYP3A4 P08684 1/20 0.49
CYP2D6 P10635 1/20 0.49
CYP2C9 P11712 1/20 0.49
THPO P40225 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5341311 0.86 MTNR1A (0.67) MTNR1AMTNR1BHTR1ASLC6A4HSD11B1
SCHEMBL9836327 0.84 MTNR1A (0.78) MTNR1AMTNR1BHTR1ASLC6A4HSD11B1
SCHEMBL6165281 0.84 HSD11B1 (0.58) HTR1ASLC6A4HSD11B1HTR2ADRD2
SCHEMBL7710792 0.82 HTR1D (0.67) MTNR1AMTNR1BHTR1ASLC6A4HTR2A
SCHEMBL21255991 0.81 MTNR1A (0.60) MTNR1AMTNR1BHTR1ASLC6A4HSD11B1
SCHEMBL16801572 0.81 MTNR1A (0.64) MTNR1AMTNR1BHTR1ASLC6A4HSD11B1
SCHEMBL5351948 0.80 MTNR1A (0.62) MTNR1AMTNR1BHTR1ASLC6A4HSD11B1
SCHEMBL28380406 0.79 MTNR1A (0.61) MTNR1AMTNR1BHTR1ASLC6A4HSD11B1
SCHEMBL24069043 0.79 MTNR1A (0.57) MTNR1AMTNR1BHTR1ASLC6A4HTR2A
Oxalic Acid SCHEMBL9030775 0.78 SLC6A4 (0.60) MTNR1AMTNR1BHTR1ASLC6A4HTR2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1562891-A1 4-AMINOMETHYL-1-ARYL-CYCLOHEXYLAMINE DERIVATIVES Grünenthal GmbH (DE) 2005-08-17 EP claimed
WO-2004043899-A1 4-AMINOMETHYL-1-ARYL-CYCLOHEXYLAMINE DERIVATIVES Grünenthal GmbH (DE) 2004-05-27 WO claimed
EP-1562891-A1 4-AMINOMETHYL-1-ARYL-CYCLOHEXYLAMINE DERIVATIVES Grünenthal GmbH (DE) 2005-08-17 EP disclosed
WO-2004043899-A1 4-AMINOMETHYL-1-ARYL-CYCLOHEXYLAMINE DERIVATIVES Grünenthal GmbH (DE) 2004-05-27 WO disclosed