Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 5/20 | 0.70 |
| ▸ | DRD2 | P14416 | 5/20 | 0.70 |
| ▸ | HTR2A | P28223 | 5/20 | 0.70 |
| ▸ | DRD3 | P35462 | 5/20 | 0.70 |
| ▸ | DRD1 | P21728 | 3/20 | 0.70 |
| ▸ | DRD5 | P21918 | 2/20 | 0.70 |
| ▸ | HRH1 | P35367 | 4/20 | 0.70 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.70 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.70 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.68 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.64 |
| ▸ | USP2 | O75604 | 1/20 | 0.64 |
| ▸ | HPGD | P15428 | 1/20 | 0.64 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.62 |
| ▸ | HRH2 | P25021 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 3/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6162706 | 0.85 | HTR1A (0.79) | HTR1ADRD2HTR2ADRD3DRD1 | |
| SCHEMBL7371738 | 0.84 | HRH3 (0.86) | ALDH1A1USP2HPGDHRH3LMNA | |
| SCHEMBL8011318 | 0.81 | DRD2 (0.69) | HTR1ADRD2HTR2ADRD3DRD1 | |
| SCHEMBL1728918 | 0.80 | USP2 (0.78) | HTR1ADRD2HTR2ADRD3DRD1 | |
| SCHEMBL11277312 | 0.79 | SLC6A2 (0.68) | HTR1ADRD2HTR2ADRD3DRD1 | |
| SCHEMBL596663 | 0.78 | SLC6A2 (0.72) | HTR1ADRD2HTR2ADRD3DRD1 | |
| SCHEMBL7135467 | 0.77 | PSMB1 (0.82) | HRH3LMNAMEN1HTTKMT2A | |
| SCHEMBL490523 | 0.77 | MEN1 (1.00) | ALDH1A1USP2HPGDHRH3LMNA | |
| SCHEMBL10835875 | 0.77 | DRD2 (0.70) | HTR1ADRD2HTR2ADRD3DRD1 | |
| SCHEMBL4348291 | 0.77 | SLC6A2 (0.68) | HTR1ADRD2HTR2ADRD3DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0755923-B1 | Ameliorant or remedy for symptoms caused by Ischemic diseases and Phenylpiperidine compounds useful therefor | DAIICHI SUNTORY PHARMA CO LTD (JP) | 2005-05-04 | — | — | EP | disclosed |
| US-6469010-B1 | COMPOSITION ALSO FOR ALLEVIATION OR TREATMENT OF SYMPTOMS DERIVED FROM SEIZURES, EPILEPSY AND MIGRAINE HEADACHES, AND SUPPRESSION OF CALCIUM ION OVERLOAD | SUNTORY LIMITED (JP) | 2002-10-22 | — | — | US | disclosed |
| US-6048876-A | ANTICONVULSANTS; ANTIEPILEPIC AGENT | SUNTORY LIMITED (JP) | 2000-04-11 | — | — | US | disclosed |
| EP-0755923-A1 | AMELIORANT OR REMEDY FOR SYMPTOMS CAUSED BY ISCHEMIC DISEASES AND COMPOUNDS USEFUL THEREFOR | SUNTORY LIMITED (JP) | 1997-01-29 | — | — | EP | disclosed |