Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 13/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | RAB9A | P51151 | 5/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.40 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | FBP1 | P09467 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL289268 | 0.92 | KDM4E (0.46) | KDM4EGAAALDH1A1RAB9AL3MBTL1 | |
| SCHEMBL3436682 | 0.80 | KDM4E (0.58) | KDM4EGAAALDH1A1RAB9AL3MBTL1 | |
| SCHEMBL27567650 | 0.78 | KDM4E (0.55) | KDM4EGAAALDH1A1RAB9AL3MBTL1 | |
| SCHEMBL851867 | 0.77 | SMN1; SMN2 (0.51) | KDM4EGAAALDH1A1RAB9AL3MBTL1 | |
| SCHEMBL6168006 | 0.77 | KDM4E (0.57) | KDM4EGAAALDH1A1RAB9AL3MBTL1 | |
| SCHEMBL27503350 | 0.77 | KDM4E (0.50) | KDM4EGAAALDH1A1RAB9AL3MBTL1 | |
| SCHEMBL290100 | 0.76 | CYP2A6 (0.40) | — | |
| SCHEMBL10091957 | 0.74 | KDM4E (0.61) | KDM4EGAAALDH1A1RAB9AL3MBTL1 | |
| SCHEMBL289322 | 0.73 | CYP2A6 (0.48) | KDM4EMAPTLMNA | |
| SCHEMBL289837 | 0.72 | DPP4 (0.53) | KDM4EGAAALDH1A1RAB9AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427447-A2 | SMALL MOLECULE INHIBITORS OF INFLUENZA A AND B VIRUS AND RESPIRATORY SYNCYTIAL VIRUS REPLICATION | Pike Pharma GmbH (CH) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010128163-A2 | SMALL MOLECULE INHIBITORS OF INFLUENZA A AND B VIRUS AND RESPIRATORY SYNCYTIAL VIRUS REPLICATION | PIKE PHARMA GMBH (CH) | 2010-11-11 | — | — | WO | disclosed |