SCHEMBL6168317

SCHEMBL6168317

CC(C)(C)Nc1nc(Cl)nc(Cl)n1

nearest known ligand 0.90

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.90
SMN1; SMN2 Q16637 2/20 0.90
PDE4A P27815 4/20 0.75
CYP1A2 P05177 2/20 0.75
CYP2C19 P33261 2/20 0.75
KMT2A Q03164 2/20 0.62
GAA P10253 2/20 0.60
NPC1 O15118 2/20 0.58
RAB9A P51151 1/20 0.58
MAPT P10636 2/20 0.52
NPSR1 Q6W5P4 1/20 0.49
ALDH1A1 P00352 2/20 0.42
ALOX15 P16050 1/20 0.42
TSHR P16473 1/20 0.42
MEN1 O00255 1/20 0.42
CYP2D6 P10635 1/20 0.42
CYP2C9 P11712 1/20 0.42
TDP1 Q9NUW8 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9387084 0.95 LMNA (1.00) LMNASMN1; SMN2PDE4ACYP1A2CYP2C19
SCHEMBL8639738 0.86 PDE4A (1.00) LMNASMN1; SMN2PDE4ACYP1A2CYP2C19
SCHEMBL2491819 0.84 LMNA (0.72) LMNASMN1; SMN2PDE4ACYP1A2CYP2C19
SCHEMBL27574020 0.81 LMNA (0.67) LMNASMN1; SMN2PDE4ACYP1A2CYP2C19
Terbuthylazine SCHEMBL8539245 0.81 KMT2A (0.74) LMNASMN1; SMN2PDE4ACYP1A2CYP2C19
SCHEMBL8071977 0.81 SMN1; SMN2 (0.67) LMNASMN1; SMN2PDE4ACYP1A2CYP2C19
Terbuthylazine SCHEMBL9715292 0.81 KMT2A (0.74) LMNASMN1; SMN2PDE4ACYP1A2CYP2C19
Terbuthylazine SCHEMBL23642 0.81 KMT2A (0.74) LMNASMN1; SMN2PDE4ACYP1A2CYP2C19
SCHEMBL10619199 0.80 SMN1; SMN2 (0.74) LMNASMN1; SMN2PDE4ACYP1A2CYP2C19
Terbuthylazine SCHEMBL27492098 0.80 KMT2A (0.72) LMNASMN1; SMN2PDE4ACYP1A2CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112608516-B Multifunctional light-stable composition and preparation method thereof 沈阳化工研究院有限公司 2022-04-08 CN claimed
CN-112608516-A Multifunctional light-stable composition and preparation method thereof 沈阳化工研究院有限公司 2021-04-06 CN claimed
US-11827920-B2 Nanostructure, a biosensor including the nanostructure, and a screening method POSTECH Research and Business Development Foundation (KR) 2023-11-28 US disclosed
US-11827920-B2 Nanostructure, a biosensor including the nanostructure, and a screening method POSTECH Research and Business Development Foundation (KR) 2023-11-28 US disclosed
US-20230139797-A1 FLUORESCENT DETECTION OF AMINES AND HYDRAZINES AND ASSAYING METHODS THEREOF ILLUMINA, INC. 2023-05-04 US disclosed
CN-112608516-B Multifunctional light-stable composition and preparation method thereof 沈阳化工研究院有限公司 2022-04-08 CN disclosed
CN-112608516-A Multifunctional light-stable composition and preparation method thereof 沈阳化工研究院有限公司 2021-04-06 CN disclosed
US-20190225880-A1 FLUORESCENT DETECTION OF AMINES AND HYDRAZINES AND ASSAYING METHODS THEREOF ILLUMINA, INC. (US) 2019-07-25 US disclosed
EP-1133490-B1 PIPERAZINONE DERIVATIVES CIBA SC HOLDING AG (CH) 2005-07-27 EP disclosed
US-6596461-B1 Useful for stabilizing an organic material against degradation induced by light, heat or oxidation CIBA SPECIALTY CHEMICALS CORPORATION 2003-07-22 US disclosed
US-6514485-B1 Combinations of sunscreens 3V SIGMA S.P.A. (IT) 2003-02-04 US disclosed
EP-1133490-A1 PIPERAZINONE DERIVATIVES Ciba SC Holding AG (CH) 2001-09-19 EP disclosed
EP-1027883-A2 Combinations of sunscreen agents with UV-A and UV-B filtering properties 3V SIGMA S.p.A (IT) 2000-08-16 EP disclosed
WO-2000031069-A1 PIPERAZINONE DERIVATIVES CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 2000-06-02 WO disclosed
US-5573922-A COMPETITIVE POLYCLONAL ANTIBODY BINDING, TESTING WATER SAMPLES BOEHRINGER MANNHEIM GMBH (DE) 1996-11-12 US disclosed
EP-0622633-A2 Immunological detection of triazine Roche Diagnostics GmbH (DE) 1994-11-02 EP disclosed
US-4981964-A PHOTOSTABILIZERS ICI AMERICAS INC. (US) 1991-01-01 US disclosed
EP-0373892-A1 Tetramethyl piperidyl terminated triazine oligomeric esters and amides ICI AMERICAS INC. (US) 1990-06-20 EP disclosed
EP-0373839-A1 Oligomeric polyesters and polyamides containing dipiperidyl triazine groups ICI AMERICAS INC. (US) 1990-06-20 EP disclosed
US-4889882-A RADIATION RESISTANCE, PHOTOSTABILITY POLYMER ADDITIVE ICI AMERICAS INC. (US) 1989-12-26 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190225880-A1 FLUORESCENT DETECTION OF AMINES AND HYDRAZINES AND ASSAYING METHODS THEREOF NAT1, ALDH7A1, PAH LMNA 415/4885SMN1; SMN2 3066/4885PDE4A 2812/4885
US-20230139797-A1 FLUORESCENT DETECTION OF AMINES AND HYDRAZINES AND ASSAYING METHODS THEREOF NAT1, ALDH7A1, PAH LMNA 415/4885SMN1; SMN2 3066/4885PDE4A 2812/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.