Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 15/20 | 0.44 |
| ▸ | DPP9 | Q86TI2 | 11/20 | 0.44 |
| ▸ | DPP7 | Q9UHL4 | 10/20 | 0.44 |
| ▸ | DPP8 | Q6V1X1 | 7/20 | 0.44 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.40 |
| ▸ | CPA1 | P15085 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2469254 | 0.79 | EPHX1 (0.54) | DPP4DPP9DPP7DPP8 | |
| Ammonia Solution, Strong SCHEMBL16268928 | 0.78 | EPHX1 (0.52) | DPP4DPP9DPP7DPP8 | |
| SCHEMBL27578791 | 0.76 | DPP4 (0.43) | DPP4DPP9DPP7DPP8LOXL2 | |
| SCHEMBL7426334 | 0.76 | TRPA1 (0.44) | DPP4DPP9DPP7DPP8TRPA1 | |
| SCHEMBL8910672 | 0.75 | TRPA1 (0.41) | DPP4DPP9DPP7DPP8LOXL2 | |
| SCHEMBL10821633 | 0.74 | DPP4 (0.40) | DPP4DPP9DPP7DPP8CPA1 | |
| SCHEMBL3191528 | 0.73 | SLC6A4 (0.58) | DPP4DPP7LOXL2TRPA1 | |
| SCHEMBL3674133 | 0.73 | LOXL2 (0.52) | DPP4DPP7LOXL2TRPA1CPA1 | |
| SCHEMBL8492336 | 0.73 | LOXL2 (0.50) | DPP4DPP9DPP7DPP8LOXL2 | |
| SCHEMBL3285405 | 0.72 | EPHX1 (0.50) | DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1519920-A1 | NOVEL TETRAHYDROPYRIDINE DERIVATIVES AS RENIN INHIBITORS | Actelion Pharmaceuticals Ltd. (CH) | 2005-04-06 | — | — | EP | disclosed |
| EP-1501830-A1 | 7-ARYL-3,9-DIAZABICYCLO[3.3.1]NON-6-ENE DERIVATIVES AND THEIR USE AS RENIN INHIBITORS IN THE TREATMENT OF HYPERTENSION, CARDIOVASCULAR OR RENAL DISEASES | Actelion Pharmaceuticals Ltd. (CH) | 2005-02-02 | — | — | EP | disclosed |
| WO-2004105762-A1 | MEDICAL USE OF DIAZABICYCLONONENE DERIVATIVES AS INHIBITORS OF PARASITE ASPARTIC PROTEASES | ACTELION PHARMACEUTICALS LTD (CH) | 2004-12-09 | — | — | WO | disclosed |
| WO-2004002957-A1 | NOVEL TETRAHYDROPYRIDINE DERIVATIVES AS RENIN INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2004-01-08 | — | — | WO | disclosed |
| WO-2003093267-A1 | 7-ARYL-3,9-DIAZABICYCLO(3.3.1)NON-6-ENE DERIVATIVES AND THEIR USE AS RENIN INHIBITORS IN THE TREATMENT OF HYPERTENSION, CARDIOVASCULAR OR RENAL DISEASES | ACTELION PHARMACEUTICALS LTD (CH) | 2003-11-13 | — | — | WO | disclosed |