Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 5/20 | 0.46 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.46 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.46 |
| ▸ | P2RX7 | Q99572 | 10/20 | 0.44 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.39 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27774992 | 0.81 | P2RX7 (0.48) | P2RX7ABCB11MAPK14MEN1NR1I2 | |
| SCHEMBL3582300 | 0.81 | TSHR (0.42) | P2RX7ABCB11MEN1NR1I2KMT2A | |
| SCHEMBL10439124 | 0.78 | NPC1 (0.55) | KMT2A | |
| SCHEMBL10439328 | 0.78 | MAPK14 (0.45) | P2RX7ABCB11MAPK14MEN1NR1I2 | |
| SCHEMBL3346080 | 0.77 | P2RX7 (0.47) | P2RX7ABCB11MEN1NR1I2KMT2A | |
| SCHEMBL3348732 | 0.77 | P2RX7 (0.58) | P2RX7ABCB11MEN1NR1I2KMT2A | |
| SCHEMBL6242523 | 0.76 | CNOT7 (0.51) | P2RX7ABCB11MEN1NR1I2KMT2A | |
| SCHEMBL3586380 | 0.76 | IDO1 (0.52) | P2RX7ABCB11 | |
| SCHEMBL13548231 | 0.75 | P2RX7 (0.40) | P2RX7ABCB11MEN1NR1I2KMT2A | |
| SCHEMBL10439310 | 0.74 | NPBWR1 (0.48) | P2RX7ABCB11MEN1NR1I2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1581232-B1 | 3-(3,5-DIOXO-4,5-DIHYDRO-3H-(1,2,4)TRIAZIN-2-YL)-BENZAMIDE DERIVATIVE AS P2X7-INHIBITOR FOR THE TREATMENT OF INFLAMMATORY DISEASES | PFIZER PROD INC (US) | 2014-04-09 | — | — | EP | disclosed |
| CN-1732006-A | 3-(3,5-dioxo-4,5-dihydro-3h-(1,2,4)triazin-2-yl)-benzamide derivatives as P2X7-inhibitors for the treatment of inflammatory diseases | PFIZER PROD INC (US) | 2006-02-08 | — | — | CN | disclosed |
| EP-1581232-A1 | 3-(3,5-DIOXO-4,5-DIHYDRO-3H-(1,2,4)TRIAZIN-2-YL)-BENZAMIDE DERIVATIVES AS P2X7-INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISEASES | Pfizer Products Inc. (US) | 2005-10-05 | — | — | EP | disclosed |
| WO-2004058270-A1 | 3-(3,5-DIOXO-4,5-DIHYDRO-3H-(1,2,4)TRIAZIN-2-YL)-BENZAMIDE DERIVATIVES AS P2X7-INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISEASES | PFIZER PRODUCTS INC. (US) | 2004-07-15 | — | — | WO | disclosed |