Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR2 | O60603 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | NCEH1 | Q6PIU2 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3987143 | 0.84 | ALDH1A1 (0.40) | ALDH1A1KDM4EHPGDMAPTPOLB | |
| SCHEMBL3978725 | 0.78 | NCEH1 (0.57) | ALDH1A1KDM4EHPGDMAPTNCEH1 | |
| SCHEMBL15387933 | 0.76 | ALDH1A1 (0.58) | TLR2ALDH1A1KDM4EHPGDMAPT | |
| SCHEMBL3980109 | 0.73 | METAP2 (0.43) | TLR2ALDH1A1KDM4EHPGDMAPT | |
| SCHEMBL6603121 | 0.70 | USP2 (0.44) | ALDH1A1KDM4EHPGDMAPTPOLB | |
| SCHEMBL1506559 | 0.70 | ALDH1A1 (0.43) | TLR2ALDH1A1KDM4EHPGDMAPT | |
| SCHEMBL28421747 | 0.70 | NCEH1 (0.57) | ALDH1A1KDM4EHPGDMAPTNCEH1 | |
| SCHEMBL5183246 | 0.69 | MEN1 (0.39) | ALDH1A1KDM4EHPGDMAPTPOLB | |
| SCHEMBL27687463 | 0.69 | SLC6A3 (0.43) | TLR2ALDH1A1KDM4EHPGDMAPT | |
| SCHEMBL29284884 | 0.68 | USP2 (0.41) | ALDH1A1KDM4EHPGDMAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1549613-A1 | SULFONAMIDES HAVING ANTIANGIOGENIC AND ANTICANCER ACTIVITY | Abbott Laboratories (US) | 2005-07-06 | — | — | EP | disclosed |
| WO-2004033419-A1 | SULFONAMIDES HAVING ANTIANGIOGENIC AND ANTICANCER ACTIVITY | ABBOTT LABORATORIES (US) | 2004-04-22 | — | — | WO | disclosed |