Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 10/20 | 0.66 |
| ▸ | PTGS1 | P23219 | 7/20 | 0.66 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.39 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.38 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 2/20 | 0.38 |
| ▸ | MAP2 | P11137 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6181624 | 0.92 | PTGS2 (0.66) | PTGS2PTGS1KIF11 | |
| SCHEMBL6170712 | 0.91 | PTGS2 (0.53) | PTGS2PTGS1GABRA1GABRG2GABRB3 | |
| SCHEMBL6172560 | 0.87 | PTGS2 (0.50) | PTGS2PTGS1 | |
| SCHEMBL6171485 | 0.87 | PTGS2 (0.56) | PTGS2PTGS1KIF11 | |
| SCHEMBL6174674 | 0.85 | PTGS2 (0.68) | PTGS2PTGS1 | |
| SCHEMBL6171838 | 0.85 | PTGS2 (0.67) | PTGS2PTGS1KIF11GABRA1GABRG2 | |
| SCHEMBL6168891 | 0.85 | PTGS2 (0.67) | PTGS2PTGS1GABRA1GABRG2GABRB3 | |
| SCHEMBL7202770 | 0.85 | PTGS2 (0.48) | PTGS2PTGS1 | |
| SCHEMBL6173175 | 0.85 | PTGS2 (0.69) | PTGS2PTGS1MAP2 | |
| SCHEMBL6172104 | 0.84 | PTGS2 (0.53) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1045833-B1 | 2,3-SUBSTITUTED INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER (US) | 2005-11-02 | — | — | EP | claimed |
| US-6608070-B1 | Useful for treatment of medical condition in which prostaglandins are implicated as pathogens | NAKAO KAZUNARI (JP) | 2003-08-19 | — | — | US | claimed |
| US-6608070-B1 | Useful for treatment of medical condition in which prostaglandins are implicated as pathogens | NAKAO KAZUNARI (JP) | 2003-08-19 | — | — | US | disclosed |