SCHEMBL6169775

SCHEMBL6169775

CS(=O)(=O)c1cccc(-c2cc(Cl)cnc2N2CCCCC2)c1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CNR2 P34972 4/20 0.44
ACVR1 Q04771 2/20 0.44
PTGS2 P35354 6/20 0.43
PTGS1 P23219 4/20 0.43
ALDH1A1 P00352 2/20 0.42
NPSR1 Q6W5P4 2/20 0.42
KDM4E B2RXH2 1/20 0.42
HTT P42858 1/20 0.42
TDP1 Q9NUW8 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.42
STK4 Q13043 1/20 0.42
STK3 Q13188 1/20 0.42
LRRK2 Q5S007 1/20 0.42
NR1H2 P55055 1/20 0.41
NR1H3 Q13133 1/20 0.41
PIK3CA P42336 1/20 0.41
PIK3CG P48736 1/20 0.41
GLP1R P43220 1/20 0.41
JAK2 O60674 1/20 0.41
MTOR P42345 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6169772 0.87 PTGS2 (0.54) PTGS2PTGS1LRRK2
SCHEMBL6169315 0.83 PTGS2 (0.57) PTGS2PTGS1KDM4ENR1H2NR1H3
SCHEMBL6171319 0.82 PTGS2 (0.46) ACVR1PTGS2PTGS1ALDH1A1NPSR1
SCHEMBL6169601 0.82 PTGS2 (0.58) PTGS2PTGS1KDM4ENR1H2NR1H3
SCHEMBL6171652 0.80 IRAK4 (0.42) ACVR1PTGS2PTGS1NR1H2NR1H3
SCHEMBL6171529 0.79 FFAR2 (0.43) PTGS2PTGS1NR1H2NR1H3JAK2
SCHEMBL6069633 0.79 PTGS2 (0.51) PTGS2PTGS1NR1H2NR1H3JAK2
SCHEMBL6172216 0.78 IRAK4 (0.44) ACVR1PTGS2PTGS1NR1H2NR1H3
SCHEMBL8431729 0.77 PTGS1 (0.39) ACVR1PTGS2PTGS1NR1H2NR1H3
SCHEMBL6069781 0.76 PTGS2 (0.49) PTGS2PTGS1NR1H2NR1H3JAK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1015431-B1 2-AMINOPYRIDINES AS INHIBITORS OF CYCLOOXYGENASE-2 MERCK FROSST CANADA INC (CA) 2005-04-20 EP claimed
EP-1015431-A1 2-AMINOPYRIDINES AS INHIBITORS OF CYCLOOXYGENASE-2 Merck Frosst Canada & Co. (CA) 2000-07-05 EP claimed
WO-1999014195-A1 2-AMINOPYRIDINES AS INHIBITORS OF CYCLOOXYGENASE-2 MERCK FROSST CANADA & CO. (CA) 1999-03-25 WO claimed
EP-1015431-B1 2-AMINOPYRIDINES AS INHIBITORS OF CYCLOOXYGENASE-2 MERCK FROSST CANADA INC (CA) 2005-04-20 EP disclosed
EP-1015431-A1 2-AMINOPYRIDINES AS INHIBITORS OF CYCLOOXYGENASE-2 Merck Frosst Canada & Co. (CA) 2000-07-05 EP disclosed
US-6004950-A NON-STEROIDAL ANTIINFLAMMATORY AGENTS; ANALGESIC, ANTIPYRETICS; SIDE EFFECT REDUCTION MERCK FROSST CANADA, INC. (CA) 1999-12-21 US disclosed
WO-1999014195-A1 2-AMINOPYRIDINES AS INHIBITORS OF CYCLOOXYGENASE-2 MERCK FROSST CANADA & CO. (CA) 1999-03-25 WO disclosed