Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | GPR17 | Q13304 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.40 |
| ▸ | C5 | P01031 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | MAP2 | P11137 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6173901 | 0.90 | TSHR (0.43) | GPR17PTGS2MEN1KMT2AABCC4 | |
| SCHEMBL6170168 | 0.89 | ALOX15 (0.43) | PTGS2MEN1KMT2AABCC4C5 | |
| SCHEMBL6168377 | 0.86 | MEN1 (0.46) | GPR17PTGS2MEN1KMT2AABCC4 | |
| SCHEMBL7202586 | 0.84 | ALOX15 (0.49) | HPGDMDM2ALOX15 | |
| SCHEMBL6169060 | 0.82 | GPR17 (0.44) | GPR17PTGS2MEN1KMT2AABCC4 | |
| SCHEMBL6171214 | 0.81 | ALOX15 (0.44) | GPR17PTGS2MEN1KMT2AABCC4 | |
| SCHEMBL6169317 | 0.81 | ALOX15 (0.44) | GPR17PTGS2MEN1KMT2AABCC4 | |
| SCHEMBL6173696 | 0.79 | GPR17 (0.41) | GPR17PTGS2MEN1KMT2AABCC4 | |
| SCHEMBL6170919 | 0.79 | TUBB4A (0.42) | GPR17PTGS2MEN1KMT2AABCC4 | |
| SCHEMBL6171794 | 0.79 | POLB (0.42) | GPR17PTGS2KMT2ALMNAMDM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1045833-B1 | 2,3-SUBSTITUTED INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER (US) | 2005-11-02 | — | — | EP | disclosed |
| EP-1045833-A1 | 2,3-SUBSTITUTED INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER INC. (US) | 2000-10-25 | — | — | EP | disclosed |
| WO-1999035130-A1 | 2,3-SUBSTITUTED INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER PHARMACEUTICALS INC. (JP) | 1999-07-15 | — | — | WO | disclosed |