Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 6/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.47 |
| ▸ | BRD4 | O60885 | 4/20 | 0.47 |
| ▸ | BRD2 | P25440 | 4/20 | 0.47 |
| ▸ | BRD3 | Q15059 | 4/20 | 0.47 |
| ▸ | MT-CO2 | P00403 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.42 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8478641 | 0.89 | PTGS2 (0.44) | PTGS2PTGS1ALDH1A1TSHRMAPK1 | |
| SCHEMBL8473536 | 0.88 | ALDH1A1 (0.47) | PTGS2MT-CO2ALDH1A1NPSR1TSHR | |
| SCHEMBL8478256 | 0.87 | PTGS2 (0.42) | PTGS2PTGS1SLC40A1KITHTR6 | |
| SCHEMBL8476626 | 0.87 | BRD4 (0.48) | PTGS2PTGS1BRD4BRD2BRD3 | |
| SCHEMBL8476995 | 0.87 | ALDH1A1 (0.45) | PTGS2BRD4BRD2BRD3MT-CO2 | |
| SCHEMBL8477494 | 0.86 | ALDH1A1 (0.46) | PTGS2BRD4BRD2BRD3MT-CO2 | |
| SCHEMBL8473864 | 0.86 | PTGS1 (0.42) | PTGS2PTGS1BRD4BRD2BRD3 | |
| SCHEMBL8477499 | 0.86 | PTGS2 (0.42) | PTGS2PTGS1ALDH1A1TSHRMAPK1 | |
| SCHEMBL8474166 | 0.86 | PTGS2 (0.42) | PTGS2PTGS1BRD4BRD2BRD3 | |
| SCHEMBL8478783 | 0.85 | PTGS2 (0.42) | PTGS2PTGS1ALDH1A1TSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1528059-A2 | Substituted isoxazoles for the treatment of inflammation | G.D. Searle LLC (US) | 2005-05-04 | — | — | EP | disclosed |
| EP-0809636-B1 | SUBSTITUTED ISOXAZOLES FOR THE TREATMENT OF INFLAMMATION | SEARLE & CO (US) | 2002-09-04 | — | — | EP | disclosed |
| EP-1223167-A2 | Substituted isoxazoles for the treatment of inflammation | G.D. Searle & Co. (US) | 2002-07-17 | — | — | EP | disclosed |
| US-5985902-A | TREATING INFLAMMATION AND INFLAMMATION-ASSOCIATED DISORDERS, SUCH AS ARTHRITIS | G.D. SEARLE & CO. (US) | 1999-11-16 | — | — | US | disclosed |
| US-5859257-A | ANTIINFLAMMATORY, ANTIARTHRITIC AGENTS | G. D. SEARLE & CO. (US) | 1999-01-12 | — | — | US | disclosed |
| US-5633272-A | Substituted isoxazoles for the treatment of inflammation | PHARMACIA & UPJOHN COMPANY LLC | 1997-05-27 | — | — | US | disclosed |