Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 1/20 | 0.49 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.49 |
| ▸ | APP | P05067 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 7/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6318672 | 0.82 | TDP1 (0.45) | APP | |
| SCHEMBL1986202 | 0.77 | MAOB (0.55) | APPMAOBLMNAMAPK1CYP3A4 | |
| SCHEMBL29705591 | 0.75 | LMNA (0.56) | APPMAOBLMNAMAPK1TSHR | |
| SCHEMBL2552483 | 0.75 | LMNA (0.56) | APPMAOBLMNAMAPK1TSHR | |
| SCHEMBL123591 | 0.75 | MAOB (0.53) | APPMAOBLMNAMAPK1TSHR | |
| SCHEMBL13798779 | 0.74 | CHRNB4 (0.60) | CHRNB4CHRNA3APPMAOBLMNA | |
| SCHEMBL30889109 | 0.74 | CHRNB4 (0.60) | CHRNB4CHRNA3APPMAOBLMNA | |
| SCHEMBL791805 | 0.72 | LMNA (0.53) | APPMAOBLMNAMAPK1TSHR | |
| SCHEMBL10904568 | 0.72 | MAOB (0.50) | APPMAOBLMNAMAPK1TSHR | |
| SCHEMBL11306471 | 0.72 | MAOB (0.62) | APPMAOBLMNAMAPK1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1519920-A1 | NOVEL TETRAHYDROPYRIDINE DERIVATIVES AS RENIN INHIBITORS | Actelion Pharmaceuticals Ltd. (CH) | 2005-04-06 | — | — | EP | disclosed |
| WO-2004002957-A1 | NOVEL TETRAHYDROPYRIDINE DERIVATIVES AS RENIN INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2004-01-08 | — | — | WO | disclosed |