Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6169930 | 0.82 | CHRNB4 (0.49) | APP | |
| SCHEMBL5145798 | 0.73 | CA1 (0.52) | TDP1KDM4ECA12CA1CA2 | |
| SCHEMBL705520 | 0.72 | AOC3 (0.43) | TDP1 | |
| 1-Allyloxy-4-Methoxybenzene SCHEMBL2843640 | 0.71 | ALDH1A1 (0.57) | CA12CA1CA2CA7CA9 | |
| SCHEMBL1951879 | 0.71 | ALDH1A1 (0.52) | CA12CA1CA2CA7CA9 | |
| SCHEMBL1069709 | 0.69 | LMNA (0.48) | KDM4ECA12CA1CA2CA7 | |
| SCHEMBL1069708 | 0.69 | LMNA (0.48) | KDM4ECA12CA1CA2CA7 | |
| SCHEMBL16838742 | 0.69 | TDP1 (0.73) | TDP1CA12CA1CA2CA7 | |
| SCHEMBL8055688 | 0.69 | ALDH1A1 (0.50) | KDM4ECA12CA1CA2CA7 | |
| SCHEMBL2474020 | 0.69 | KDM4E (0.60) | TDP1KDM4ECA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501830-A1 | 7-ARYL-3,9-DIAZABICYCLO[3.3.1]NON-6-ENE DERIVATIVES AND THEIR USE AS RENIN INHIBITORS IN THE TREATMENT OF HYPERTENSION, CARDIOVASCULAR OR RENAL DISEASES | Actelion Pharmaceuticals Ltd. (CH) | 2005-02-02 | — | — | EP | disclosed |
| WO-2003093267-A1 | 7-ARYL-3,9-DIAZABICYCLO(3.3.1)NON-6-ENE DERIVATIVES AND THEIR USE AS RENIN INHIBITORS IN THE TREATMENT OF HYPERTENSION, CARDIOVASCULAR OR RENAL DISEASES | ACTELION PHARMACEUTICALS LTD (CH) | 2003-11-13 | — | — | WO | disclosed |