Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.66 |
| ▸ | RAB9A | P51151 | 4/20 | 0.66 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.64 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.64 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.64 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.64 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.64 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.64 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.64 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.64 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.64 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.64 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.64 |
| ▸ | NAAA | Q02083 | 1/20 | 0.64 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.56 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9861012 | 0.94 | HDAC1 (0.72) | NPC1RAB9AHDAC1HDAC2HDAC8 | |
| SCHEMBL1337737 | 0.88 | GAA (0.63) | NPC1RAB9AHDAC1HDAC2HDAC8 | |
| SCHEMBL8779817 | 0.88 | HDAC1 (0.79) | NPC1RAB9AHDAC1HDAC2HDAC8 | |
| SCHEMBL9491686 | 0.88 | NPC1 (0.75) | NPC1RAB9AHDAC1HDAC2HDAC8 | |
| Bromide SCHEMBL11793652 | 0.86 | GAA (0.61) | NPC1RAB9AHDAC1HDAC2HDAC8 | |
| SCHEMBL9489804 | 0.86 | HDAC1 (0.82) | NPC1RAB9AHDAC1HDAC2HDAC8 | |
| SCHEMBL20734829 | 0.86 | HDAC1 (0.82) | NPC1RAB9AHDAC1HDAC2HDAC8 | |
| SCHEMBL7460068 | 0.86 | HDAC1 (0.82) | NPC1RAB9AHDAC1HDAC2HDAC8 | |
| SCHEMBL9492235 | 0.86 | HDAC1 (0.82) | NPC1RAB9AHDAC1HDAC2HDAC8 | |
| SCHEMBL9188890 | 0.86 | HDAC1 (0.82) | NPC1RAB9AHDAC1HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0936222-B1 | A method to prepare 2-(3-pyridyl)-4,5-dihydrothiazoles | DOW AGROSCIENCES LLC (US) | 2005-09-07 | — | — | EP | disclosed |
| US-6063929-A | Method to prepare dihydrothiazoles | ROHM AND HAAS COMPANY (US) | 2000-05-16 | — | — | US | disclosed |
| EP-0936222-A1 | A method to prepare 2-(3-pyridyl)-4,5-dihydrothiazoles | ROHM AND HAAS COMPANY (US) | 1999-08-18 | — | — | EP | disclosed |