Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGAL | P20701 | 1/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 3/20 | 0.36 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.36 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.35 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.35 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.35 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.35 |
| ▸ | LIPE | Q05469 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | PPARD | Q03181 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | IGF1R | P08069 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6174845 | 0.88 | NTRK1 (0.38) | ITGALARPOLBL3MBTL1NTRK1 | |
| SCHEMBL6175072 | 0.86 | IGF1R (0.48) | ITGALIGF1R | |
| SCHEMBL6170256 | 0.85 | IGF1R (0.42) | ITGALARAVPR2AVPR1AIGF1R | |
| SCHEMBL6174785 | 0.85 | ITGAL (0.41) | ITGALARKCNH2SCN9ANTRK1 | |
| SCHEMBL6171101 | 0.83 | TRPA1 (0.43) | ITGALARSCN9APOLBL3MBTL1 | |
| SCHEMBL6174753 | 0.83 | MAT2A (0.43) | ITGALARPOLBL3MBTL1IGF1R | |
| SCHEMBL6175657 | 0.82 | IGF1R (0.45) | ITGALARLIPEKCNH2SCN5A | |
| SCHEMBL6176754 | 0.82 | ITGAL (0.44) | ITGALARSCN9APOLBL3MBTL1 | |
| SCHEMBL6173435 | 0.82 | IGF1R (0.45) | ITGALARSCN9APOLBL3MBTL1 | |
| SCHEMBL6177003 | 0.81 | TDP1 (0.42) | ITGALKDRLIPEIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |