SCHEMBL6170450

SCHEMBL6170450

CC(=O)OCC1CCCN1c1ncc(C(F)(F)F)cc1-c1cccc(S(C)(=O)=O)c1

nearest known ligand 0.52

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
PTGS2 P35354 8/20 0.52
PTGS1 P23219 4/20 0.52
CHRM3 P20309 5/20 0.41
PTGDR2 Q9Y5Y4 1/20 0.39
KDM4E B2RXH2 1/20 0.38
ALDH1A1 P00352 1/20 0.38
CYP2C9 P11712 1/20 0.38
HPGD P15428 1/20 0.38
CYP2C19 P33261 1/20 0.38
MAP3K12 Q12852 1/20 0.37
TIPARP Q7Z3E1 1/20 0.37
NR1H2 P55055 2/20 0.37
NR1H3 Q13133 2/20 0.37
SLC6A9 P48067 1/20 0.36
SLC6A5 Q9Y345 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6170449 0.91 PTGS2 (0.63) PTGS2PTGS1PTGDR2
SCHEMBL6171203 0.90 PTGS2 (0.53) PTGS2PTGS1MAP3K12NR1H2NR1H3
SCHEMBL6170845 0.88 PTGS2 (0.59) PTGS2PTGS1ALDH1A1NR1H2NR1H3
SCHEMBL6169356 0.85 PTGS2 (0.56) PTGS2PTGS1NR1H2NR1H3
SCHEMBL6172953 0.84 PTGS2 (0.52) PTGS2PTGS1NR1H2NR1H3
SCHEMBL6171795 0.81 PTGS2 (0.51) PTGS2PTGS1NR1H2NR1H3
SCHEMBL6169810 0.80 PTGS2 (0.65) PTGS2PTGS1PTGDR2
SCHEMBL6171370 0.79 PTGS2 (0.70) PTGS2PTGS1PTGDR2
SCHEMBL6170843 0.79 PTGS2 (0.70) PTGS2PTGS1PTGDR2
SCHEMBL6169601 0.78 PTGS2 (0.58) PTGS2PTGS1KDM4EHPGDNR1H2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1015431-B1 2-AMINOPYRIDINES AS INHIBITORS OF CYCLOOXYGENASE-2 MERCK FROSST CANADA INC (CA) 2005-04-20 EP claimed
EP-1015431-A1 2-AMINOPYRIDINES AS INHIBITORS OF CYCLOOXYGENASE-2 Merck Frosst Canada & Co. (CA) 2000-07-05 EP claimed
WO-1999014195-A1 2-AMINOPYRIDINES AS INHIBITORS OF CYCLOOXYGENASE-2 MERCK FROSST CANADA & CO. (CA) 1999-03-25 WO claimed
EP-1015431-B1 2-AMINOPYRIDINES AS INHIBITORS OF CYCLOOXYGENASE-2 MERCK FROSST CANADA INC (CA) 2005-04-20 EP disclosed
EP-1015431-A1 2-AMINOPYRIDINES AS INHIBITORS OF CYCLOOXYGENASE-2 Merck Frosst Canada & Co. (CA) 2000-07-05 EP disclosed
US-6004950-A NON-STEROIDAL ANTIINFLAMMATORY AGENTS; ANALGESIC, ANTIPYRETICS; SIDE EFFECT REDUCTION MERCK FROSST CANADA, INC. (CA) 1999-12-21 US disclosed
WO-1999014195-A1 2-AMINOPYRIDINES AS INHIBITORS OF CYCLOOXYGENASE-2 MERCK FROSST CANADA & CO. (CA) 1999-03-25 WO disclosed