Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 7/20 | 0.55 |
| ▸ | HMOX1 | P09601 | 1/20 | 0.49 |
| ▸ | HMOX2 | P30519 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6171031 | 0.88 | ALDH1A1 (0.74) | TP53ALDH1A1HPGDTSHRSMN1; SMN2 | |
| SCHEMBL6172259 | 0.87 | TP53 (0.60) | TP53ALDH1A1HPGDTSHRSMN1; SMN2 | |
| SCHEMBL6171650 | 0.86 | ALOX15 (0.58) | TP53ALDH1A1HPGDTSHRSMN1; SMN2 | |
| SCHEMBL6171654 | 0.81 | TP53 (0.64) | TP53ALDH1A1HPGDTSHRSMN1; SMN2 | |
| SCHEMBL3057679 | 0.72 | ADORA2A (0.48) | TP53 | |
| Hydrochloric Acid SCHEMBL4056520 | 0.72 | ALDH1A1 (0.69) | TP53ALDH1A1HPGDTSHRSMN1; SMN2 | |
| SCHEMBL6173264 | 0.72 | ALDH1A1 (0.49) | TP53ALDH1A1HPGDTSHRSMN1; SMN2 | |
| SCHEMBL6173452 | 0.71 | ALDH1A1 (0.47) | TP53ALDH1A1HPGDTSHRSMN1; SMN2 | |
| SCHEMBL6173638 | 0.70 | PDE4B (0.51) | TP53ALDH1A1HPGDTSHRSMN1; SMN2 | |
| SCHEMBL21328372 | 0.69 | NR1H4 (0.42) | TP53ALDH1A1HPGDTSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1263757-A1 | BENZTHIAZOLES AS TNF AND PDE-IV INHIBITORS | Darwin Discovery Limited (GB) | 2002-12-11 | — | — | EP | claimed |
| US-6313116-B1 | PHOSPHODIESTERASE INHIBITORS | DARWIN DISCOVERY, LTD. (GB) | 2001-11-06 | — | — | US | claimed |
| WO-2001058897-A1 | BENZTHIAZOLES AS TNF AND PDE-IV INHIBITORS | DARWIN DISCOVERY LIMITED (GB) | 2001-08-16 | — | — | WO | claimed |
| EP-1263757-B1 | BENZTHIAZOLES AS TNF AND PDE-IV INHIBITORS | DARWIN DISCOVERY LTD (GB) | 2005-07-27 | — | — | EP | disclosed |
| EP-1263757-A1 | BENZTHIAZOLES AS TNF AND PDE-IV INHIBITORS | Darwin Discovery Limited (GB) | 2002-12-11 | — | — | EP | disclosed |
| US-6313116-B1 | PHOSPHODIESTERASE INHIBITORS | DARWIN DISCOVERY, LTD. (GB) | 2001-11-06 | — | — | US | disclosed |
| WO-2001058897-A1 | BENZTHIAZOLES AS TNF AND PDE-IV INHIBITORS | DARWIN DISCOVERY LIMITED (GB) | 2001-08-16 | — | — | WO | disclosed |