Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | TSHR | P16473 | 3/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.49 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7535177 | 0.85 | CHRM4 (0.39) | ALDH1A1MAPTTSHRHSD17B10CHRM4 | |
| SCHEMBL7535173 | 0.84 | BRD4 (0.39) | ALDH1A1MAPTTSHRHSD17B10CHRM4 | |
| SCHEMBL6172975 | 0.78 | ALDH1A1 (0.44) | ALDH1A1MAPTTSHRHSD17B10CHRM4 | |
| SCHEMBL1919282 | 0.77 | ALDH1A1 (0.52) | ALDH1A1MAPTTSHRHSD17B10CHRM4 | |
| SCHEMBL6173452 | 0.76 | ALDH1A1 (0.47) | ALDH1A1MAPTTSHRHSD17B10TP53 | |
| SCHEMBL6173638 | 0.75 | PDE4B (0.51) | ALDH1A1MAPTTSHRHSD17B10TP53 | |
| SCHEMBL6171031 | 0.73 | ALDH1A1 (0.74) | ALDH1A1MAPTTSHRHSD17B10TP53 | |
| SCHEMBL6171107 | 0.73 | ALDH1A1 (0.41) | ALDH1A1MAPTTSHRHSD17B10CHRM4 | |
| SCHEMBL6172259 | 0.73 | TP53 (0.60) | ALDH1A1MAPTTSHRHSD17B10TP53 | |
| SCHEMBL6170488 | 0.72 | TP53 (0.56) | ALDH1A1MAPTTSHRHSD17B10TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6313116-B1 | PHOSPHODIESTERASE INHIBITORS | DARWIN DISCOVERY, LTD. (GB) | 2001-11-06 | — | — | US | claimed |
| EP-1263757-B1 | BENZTHIAZOLES AS TNF AND PDE-IV INHIBITORS | DARWIN DISCOVERY LTD (GB) | 2005-07-27 | — | — | EP | disclosed |
| EP-1263757-A1 | BENZTHIAZOLES AS TNF AND PDE-IV INHIBITORS | Darwin Discovery Limited (GB) | 2002-12-11 | — | — | EP | disclosed |
| US-6313116-B1 | PHOSPHODIESTERASE INHIBITORS | DARWIN DISCOVERY, LTD. (GB) | 2001-11-06 | — | — | US | disclosed |
| WO-2001058897-A1 | BENZTHIAZOLES AS TNF AND PDE-IV INHIBITORS | DARWIN DISCOVERY LIMITED (GB) | 2001-08-16 | — | — | WO | disclosed |