Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | GSTP1 | P09211 | 2/20 | 0.51 |
| ▸ | CTSV | O60911 | 3/20 | 0.47 |
| ▸ | CTSL | P07711 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | MGAM | O43451 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | SI | P14410 | 2/20 | 0.46 |
| ▸ | MGAM2 | Q2M2H8 | 2/20 | 0.46 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.45 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6170426 | 0.86 | KMT2A (0.71) | MEN1NPC1RAB9AKMT2AATM | |
| SCHEMBL6169412 | 0.85 | RAB9A (0.57) | MEN1NPC1RAB9AKMT2AATM | |
| SCHEMBL6172194 | 0.81 | MEN1 (0.53) | MEN1NPC1RAB9AKMT2AATM | |
| SCHEMBL6170246 | 0.76 | KMT2A (0.50) | MEN1NPC1RAB9AKMT2AATM | |
| SCHEMBL30396449 | 0.74 | SRD5A2 (0.64) | MEN1NPC1RAB9AKMT2ACTSV | |
| SCHEMBL6171096 | 0.72 | MEN1 (0.46) | MEN1NPC1RAB9AKMT2AATM | |
| SCHEMBL30396518 | 0.72 | SRD5A2 (0.52) | MEN1NPC1RAB9AKMT2ACTSV | |
| SCHEMBL7256169 | 0.72 | CTSV (0.66) | MEN1KMT2ACTSVCTSLKDM4E | |
| SCHEMBL7197823 | 0.71 | SRD5A2 (0.67) | MEN1NPC1RAB9AKMT2ACTSV | |
| SCHEMBL2885057 | 0.70 | GSK3B (0.55) | CTSVCTSLKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1097138-B1 | PHARMACEUTICAL COMPOSITIONS COMPRISING 2-QUINOLONES | LAFON LABOR (FR) | 2005-12-07 | — | — | EP | disclosed |
| CN-1195740-C | Pharmaceutical composition containing 2-quinolinone | LAFON LABOR (FR) | 2005-04-06 | — | — | CN | disclosed |
| US-6593342-B1 | Activity on the proliferation of clonogenic cells in tumours and comprising an efficient amount of a compound selected among the compounds | LABORATOIRE L. LAFON (FR) | 2003-07-15 | — | — | US | disclosed |
| CN-1309639-A | Pharmaceutical composition containing 2-quinolinone | LAFON LABOR (FR) | 2001-08-22 | — | — | CN | disclosed |