Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | TP53 | P04637 | 4/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.40 |
| ▸ | USP2 | O75604 | 2/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14831687 | 0.84 | PTGS2 (0.38) | RAB9ASMN1; SMN2ALDH1A1KDM4EMEN1 | |
| SCHEMBL7734837 | 0.80 | ALDH1A1 (0.46) | SMN1; SMN2ALDH1A1KDM4ETP53MEN1 | |
| SCHEMBL570621 | 0.78 | ALDH1A1 (0.47) | SMN1; SMN2ALDH1A1KDM4ETP53MEN1 | |
| SCHEMBL6168967 | 0.78 | ALDH1A1 (0.43) | RAB9ASMN1; SMN2ALDH1A1KDM4ETP53 | |
| SCHEMBL1756651 | 0.77 | RBP4 (0.41) | SMN1; SMN2ALDH1A1KDM4ETP53MEN1 | |
| SCHEMBL4129795 | 0.77 | RBP4 (0.41) | SMN1; SMN2ALDH1A1KDM4ETP53MEN1 | |
| SCHEMBL4602617 | 0.77 | LCK (0.47) | RAB9ASMN1; SMN2ALDH1A1KDM4ETP53 | |
| SCHEMBL17321380 | 0.76 | ELANE (0.40) | ALDH1A1KDM4ETP53MEN1KMT2A | |
| SCHEMBL8880128 | 0.76 | RBP4 (0.39) | RAB9ASMN1; SMN2ALDH1A1KDM4ETP53 | |
| SCHEMBL18703328 | 0.76 | IP6K1 (0.50) | RAB9AALDH1A1KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1531812-A1 | FUSED HETEROARYL DERIVATIVES FOR USE AS P38 KINASE INHIBITORS IN THE TREATMENT OF I.A. RHEUMATOID ARTHRISTIS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-05-25 | — | — | EP | disclosed |
| WO-2004010995-A1 | FUSED HETEROARYL DERIVATIVES FOR USE AS P38 KINASE INHIBITORS IN THE TREATMENT OF I.A. RHEUMATOID ARTHRISTIS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-02-05 | — | — | WO | disclosed |