Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.46 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.45 |
| ▸ | CRHBP | P24387 | 1/20 | 0.44 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.44 |
| ▸ | CTPS1 | P17812 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2690814 | 0.88 | HTT (0.54) | LMNAKMT2AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL4488089 | 0.86 | CASP6 (0.60) | LMNAKMT2AMAPTALDH1A1NPSR1 | |
| SCHEMBL27944435 | 0.84 | HCAR3 (0.56) | PARP1LMNAKMT2AMAPTSMN1; SMN2 | |
| SCHEMBL6437317 | 0.81 | NPSR1 (0.52) | LMNAKMT2AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL9663706 | 0.81 | MAPK1 (0.59) | KMT2AMAPTSMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL10790188 | 0.80 | HTT (0.68) | LMNAKMT2AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL11215556 | 0.80 | NPSR1 (0.62) | LMNAKMT2AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL22535975 | 0.80 | CYP3A4 (0.55) | LMNAKMT2AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL6169182 | 0.79 | KMT2A (0.81) | LMNAKMT2AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL6259587 | 0.79 | F10 (0.52) | KMT2AMAPTSMN1; SMN2ALDH1A1DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0882718-B1 | BENZIMIDAZOLE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO (JP) | 2005-08-31 | — | — | EP | disclosed |
| US-6352985-B1 | CARDIOVASCULAR DISORDERS OR GASTROINTESTINAL DISORDERS, DIABETES (TYPE II DIABETES), DIABETIC COMPLICATIONS METHOD FOR LOWERING THE BLOOD SUGAR LEVEL OF A PATIENT, | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-03-05 | — | — | US | disclosed |
| US-6166219-A | Benzimidazole derivatives | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-12-26 | — | — | US | disclosed |
| EP-0882718-A1 | BENZIMIDAZOLE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-12-09 | — | — | EP | disclosed |