Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | TTR | P02766 | 1/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | TYR | P14679 | 1/20 | 0.44 |
| ▸ | CA7 | P43166 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6171196 | 1.00 | ALDH1A1 (0.50) | ALDH1A1KDM4EMAPTKMT2AALOX15 | |
| SCHEMBL6169905 | 0.87 | ALDH1A1 (0.50) | ALDH1A1KDM4EMAPTKMT2AALOX15 | |
| SCHEMBL6169914 | 0.87 | ALDH1A1 (0.50) | ALDH1A1KDM4EMAPTKMT2AALOX15 | |
| SCHEMBL8071407 | 0.84 | TTR (0.49) | MAPTCYP1A2CYP2C9CYP2C19TTR | |
| SCHEMBL6505316 | 0.83 | MAPT (0.53) | ALDH1A1KDM4EMAPTKMT2AALOX15 | |
| SCHEMBL5542490 | 0.83 | MAPT (0.53) | ALDH1A1KDM4EMAPTKMT2AALOX15 | |
| SCHEMBL3179934 | 0.83 | ABL1 (0.51) | ALDH1A1KDM4EMAPTKMT2AALOX15 | |
| SCHEMBL6171560 | 0.83 | ALDH1A1 (0.49) | ALDH1A1KDM4EMAPTKMT2AALOX15 | |
| SCHEMBL706048 | 0.83 | MAPT (0.53) | ALDH1A1KDM4EMAPTKMT2AALOX15 | |
| SCHEMBL6169857 | 0.83 | MAPT (0.53) | ALDH1A1KDM4EMAPTKMT2AALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1045833-B1 | 2,3-SUBSTITUTED INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER (US) | 2005-11-02 | — | — | EP | disclosed |
| US-6608070-B1 | Useful for treatment of medical condition in which prostaglandins are implicated as pathogens | NAKAO KAZUNARI (JP) | 2003-08-19 | — | — | US | disclosed |
| EP-1065206-B1 | Tetrazolylalkyl indole compounds as anti-inflammatory and analgesic agents | PFIZER (US) | 2002-10-09 | — | — | EP | disclosed |
| EP-1065206-A1 | Tetrazolylalkyl indole compounds as anti-inflammatory and analgesic agents | PFIZER INC. (US) | 2001-01-03 | — | — | EP | disclosed |