Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.51 |
| ▸ | TUBB | P07437 | 1/20 | 0.51 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.51 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.51 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.51 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.51 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.51 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.51 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.51 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.51 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.51 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.51 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.51 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.51 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.51 |
| ▸ | LY96 | Q9Y6Y9 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL706048 | 1.00 | MAPT (0.53) | MAPTALDH1A1MEN1KMT2ATUBB4A | |
| SCHEMBL6170877 | 0.88 | JUN (0.53) | MAPTALDH1A1MEN1KMT2ALY96 | |
| SCHEMBL6170881 | 0.88 | JUN (0.53) | MAPTALDH1A1MEN1KMT2ALY96 | |
| SCHEMBL2700483 | 0.86 | THRB (0.56) | MAPTALDH1A1MEN1KMT2ATUBB4A | |
| SCHEMBL2700488 | 0.86 | THRB (0.56) | MAPTALDH1A1MEN1KMT2ATUBB4A | |
| SCHEMBL18069259 | 0.85 | ALDH1A1 (0.49) | MAPTALDH1A1MEN1KMT2ATUBB4A | |
| SCHEMBL6171780 | 0.84 | ALDH1A1 (0.43) | MAPTALDH1A1MEN1KMT2ANFKB1 | |
| SCHEMBL6171773 | 0.84 | ALDH1A1 (0.43) | MAPTALDH1A1MEN1KMT2ANFKB1 | |
| SCHEMBL6171189 | 0.83 | ALDH1A1 (0.50) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL6171196 | 0.83 | ALDH1A1 (0.50) | MAPTALDH1A1MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1045833-B1 | 2,3-SUBSTITUTED INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER (US) | 2005-11-02 | — | — | EP | disclosed |
| US-6608070-B1 | Useful for treatment of medical condition in which prostaglandins are implicated as pathogens | NAKAO KAZUNARI (JP) | 2003-08-19 | — | — | US | disclosed |