Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 14/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6172175 | 0.91 | IGF1R (0.37) | IGF1RCYP3A4GAACYP2C9CYP2C19 | |
| SCHEMBL6174742 | 0.87 | IGF1R (0.40) | IGF1RCYP3A4GAACYP2C9CYP2C19 | |
| SCHEMBL6175557 | 0.87 | GAA (0.36) | IGF1RCYP3A4GAACYP2C9CYP2C19 | |
| SCHEMBL6175144 | 0.86 | IGF1R (0.39) | IGF1RCYP3A4GAACYP2C9CYP2C19 | |
| SCHEMBL6174077 | 0.84 | CYP3A4 (0.49) | IGF1RCYP3A4GAACYP2C9CYP2C19 | |
| SCHEMBL2938900 | 0.84 | IGF1R (0.56) | IGF1R | |
| SCHEMBL6173492 | 0.83 | KCNK2 (0.41) | IGF1RCYP3A4GAACYP2C9CYP2C19 | |
| SCHEMBL6171796 | 0.83 | IGF1R (0.36) | IGF1RCYP3A4GAACYP2C9CYP2C19 | |
| SCHEMBL6171771 | 0.82 | IGF1R (0.41) | IGF1RMAPTKMT2A | |
| SCHEMBL6173746 | 0.82 | LMNA (0.42) | IGF1RCYP3A4GAACYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |