Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 15/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.33 |
| ▸ | KDM5A | P29375 | 1/20 | 0.33 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6173492 | 0.88 | KCNK2 (0.41) | IGF1RALDH1A1CYP3A4GAACYP2C9 | |
| SCHEMBL6174742 | 0.87 | IGF1R (0.40) | IGF1RALDH1A1CYP3A4GAACYP2C9 | |
| SCHEMBL6171771 | 0.87 | IGF1R (0.41) | IGF1RNTRK1KDM4C | |
| SCHEMBL6171502 | 0.86 | IGF1R (0.39) | IGF1RALDH1A1CYP3A4GAACYP2C9 | |
| SCHEMBL6173999 | 0.84 | IGF1R (0.40) | IGF1RALDH1A1GAA | |
| SCHEMBL6174077 | 0.84 | CYP3A4 (0.49) | IGF1RALDH1A1CYP3A4GAACYP2C9 | |
| SCHEMBL6172175 | 0.83 | IGF1R (0.37) | IGF1RALDH1A1CYP3A4GAACYP2C9 | |
| SCHEMBL2932168 | 0.83 | IGF1R (0.56) | IGF1R | |
| SCHEMBL6171072 | 0.83 | IGF1R (0.42) | IGF1RALDH1A1NTRK1KDM4C | |
| SCHEMBL6173746 | 0.82 | LMNA (0.42) | IGF1RALDH1A1CYP3A4GAACYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |