Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | KCNK2 | O95069 | 3/20 | 0.45 |
| ▸ | KCNK10 | P57789 | 2/20 | 0.45 |
| ▸ | IGF1R | P08069 | 5/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6173746 | 0.91 | LMNA (0.42) | CYP3A4GAACYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL6173492 | 0.91 | KCNK2 (0.41) | CYP3A4GAACYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL6174981 | 0.90 | CYP3A4 (0.51) | CYP3A4GAACYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL6173115 | 0.85 | IGF1R (0.39) | ALDH1A1KCNK2KCNK10IGF1RMEN1 | |
| SCHEMBL6175144 | 0.84 | IGF1R (0.39) | CYP3A4GAACYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL6171502 | 0.84 | IGF1R (0.39) | CYP3A4GAACYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL6174742 | 0.83 | IGF1R (0.40) | CYP3A4GAACYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL6277096 | 0.83 | CYP3A4 (0.43) | CYP3A4GAACYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL2941443 | 0.83 | IGF1R (0.56) | KCNK2KCNK10IGF1R | |
| SCHEMBL6173999 | 0.83 | IGF1R (0.40) | GAAALDH1A1KCNK2KCNK10IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |