Sugi Predict

Sugi Predict / Compounds / SCHEMBL6171604

SCHEMBL6171604

SCHEMBL6171604

CC1(Cc2cc(Cl)nc3ccccc23)NC(=O)N(c2ccc(SC(F)(F)F)cc2)C1=O

nearest known ligand 0.42

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ IGF1R P08069 16/20 0.42
▸ ITGAL P20701 1/20 0.37
▸ AR P10275 2/20 0.36
▸ NTRK1 P04629 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6175823 0.90 IGF1R (0.39) IGF1RAR
SCHEMBL6175753 0.90 IGF1R (0.42) IGF1RITGALARNTRK1
SCHEMBL6172631 0.89 IGF1R (0.42) IGF1RITGALARNTRK1
SCHEMBL6175012 0.88 IGF1R (0.45) IGF1RARNTRK1
SCHEMBL6176994 0.84 KDM4E (0.40) IGF1RNTRK1
SCHEMBL6173427 0.84 IGF1R (0.45) IGF1RARNTRK1
SCHEMBL6175028 0.84 IGF1R (0.45) IGF1RARNTRK1
Trifluoroacetic Acid SCHEMBL17558379 0.82 IGF1R (0.42) IGF1RARNTRK1
SCHEMBL6174253 0.81 IGF1R (0.40) IGF1RITGALARNTRK1
SCHEMBL2940850 0.80 IGF1R (0.62) IGF1R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1599464-A2 NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS Aventis Pharma S.A. (FR) 2005-11-30 — — EP disclosed
WO-2004070050-A2 CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS AVENTIS PHARMA S.A. (FR) 2004-08-19 — — WO disclosed