Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | IGF1R | P08069 | 12/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.34 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.34 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6172524 | 0.86 | IGF1R (0.45) | KDM4EGAAACHEL3MBTL1ALDH1A1 | |
| SCHEMBL6175753 | 0.85 | IGF1R (0.42) | IGF1RNTRK1TRPV4 | |
| SCHEMBL6175823 | 0.85 | IGF1R (0.39) | IGF1R | |
| SCHEMBL6171604 | 0.84 | IGF1R (0.42) | IGF1RNTRK1 | |
| SCHEMBL6172631 | 0.84 | IGF1R (0.42) | IGF1RNTRK1 | |
| SCHEMBL6175012 | 0.84 | IGF1R (0.45) | IGF1RNTRK1 | |
| SCHEMBL2939764 | 0.82 | IGF1R (0.54) | IGF1R | |
| SCHEMBL6172238 | 0.81 | KDM4E (0.39) | KDM4EGAAACHEL3MBTL1ALDH1A1 | |
| SCHEMBL6174914 | 0.81 | IGF1R (0.40) | IGF1RNTRK1 | |
| SCHEMBL6173427 | 0.80 | IGF1R (0.45) | IGF1RNTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |