Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.36 |
| ▸ | IGF1R | P08069 | 5/20 | 0.36 |
| ▸ | GCGR | P47871 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6177581 | 0.87 | IGF1R (0.50) | IGF1R | |
| SCHEMBL6174213 | 0.87 | IGF1R (0.40) | GAACYP3A4CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL6171765 | 0.85 | IGF1R (0.41) | GAACYP3A4CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL6175032 | 0.85 | MAPK1 (0.43) | IGF1RNAMPTTRPV1 | |
| SCHEMBL6173728 | 0.85 | MEN1 (0.47) | IGF1RNAMPT | |
| SCHEMBL6174271 | 0.85 | LMNA (0.43) | GAACYP3A4CYP2C9CYP2C19IGF1R | |
| SCHEMBL6172079 | 0.84 | IGF1R (0.47) | GAACYP3A4CYP2C9CYP2C19IGF1R | |
| SCHEMBL6175298 | 0.84 | GRM5 (0.45) | ALDH1A1IGF1RGCGRTRPV1 | |
| SCHEMBL6177003 | 0.83 | TDP1 (0.42) | GAAIGF1RGCGR | |
| SCHEMBL2939943 | 0.82 | IGF1R (0.56) | IGF1RGCGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |