Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 3/20 | 0.40 |
| ▸ | BRAF | P15056 | 4/20 | 0.40 |
| ▸ | IGF1R | P08069 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 3/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | P2RY1 | P47900 | 3/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | RAF1 | P04049 | 1/20 | 0.39 |
| ▸ | IDH1 | O75874 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6175032 | 0.92 | MAPK1 (0.43) | MEN1KMT2AEPHX2PTGS2BRAF | |
| SCHEMBL6171765 | 0.89 | IGF1R (0.41) | MEN1KMT2AEPHX2PTGS2KDR | |
| SCHEMBL6175174 | 0.88 | ABL1 (0.47) | MEN1KMT2AEPHX2PTGS2KDR | |
| SCHEMBL6173148 | 0.85 | IGF1R (0.40) | KMT2AEPHX2PTGS2KDRIGF1R | |
| SCHEMBL6172735 | 0.85 | IGF1R (0.42) | EPHX2KDRIGF1R | |
| SCHEMBL6177003 | 0.85 | TDP1 (0.42) | KMT2AKDRBRAFIGF1RKIT | |
| SCHEMBL6177217 | 0.85 | TLR7 (0.39) | IGF1RNAMPT | |
| SCHEMBL6173624 | 0.85 | IGF1R (0.42) | KDRIGF1RNAMPT | |
| SCHEMBL6172079 | 0.84 | IGF1R (0.47) | KMT2AIGF1R | |
| SCHEMBL6174016 | 0.84 | IGF1R (0.41) | KDRIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |