Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 2/20 | 0.59 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 7/20 | 0.57 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.44 |
| ▸ | F7 | P08709 | 1/20 | 0.44 |
| ▸ | F3 | P13726 | 1/20 | 0.44 |
| ▸ | DAO | P14920 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL717013 | 0.89 | HRH4 (0.64) | FLT3PDGFRBHRH4MEN1KMT2A | |
| SCHEMBL22529373 | 0.83 | HRH4 (0.50) | FLT3HRH4MEN1KMT2ARXFP1 | |
| SCHEMBL20853218 | 0.83 | KMT2A (0.65) | FLT3PDGFRBHRH4MEN1KMT2A | |
| SCHEMBL6170623 | 0.82 | ATP6AP1 (0.44) | FLT3PDGFRBHRH4MEN1KMT2A | |
| SCHEMBL3246966 | 0.81 | PDGFRB (0.57) | FLT3PDGFRBDAO | |
| SCHEMBL2644028 | 0.80 | MLYCD (0.44) | FLT3PDGFRBHRH4MEN1KMT2A | |
| SCHEMBL5917452 | 0.79 | ALOX15 (0.71) | FLT3PDGFRBALOX15HRH4F7 | |
| SCHEMBL30920590 | 0.78 | RXFP1 (0.51) | FLT3PDGFRBHRH4MEN1KMT2A | |
| SCHEMBL30204895 | 0.78 | CDK2 (0.41) | FLT3PDGFRBALOX15HRH4MEN1 | |
| SCHEMBL7879683 | 0.78 | ALOX15 (0.55) | FLT3PDGFRBALOX15HRH4HAO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1045833-B1 | 2,3-SUBSTITUTED INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER (US) | 2005-11-02 | — | — | EP | disclosed |
| US-6608070-B1 | Useful for treatment of medical condition in which prostaglandins are implicated as pathogens | NAKAO KAZUNARI (JP) | 2003-08-19 | — | — | US | disclosed |
| EP-1045833-A1 | 2,3-SUBSTITUTED INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER INC. (US) | 2000-10-25 | — | — | EP | disclosed |
| WO-1999035130-A1 | 2,3-SUBSTITUTED INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER PHARMACEUTICALS INC. (JP) | 1999-07-15 | — | — | WO | disclosed |