Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 3/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.34 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6173386 | 0.91 | ALDH1A1 (0.41) | ALDH1A1RXFP1MEN1KMT2AGAA | |
| SCHEMBL6174642 | 0.87 | ALDH1A1 (0.42) | ALDH1A1MEN1KMT2AGAACYP2C9 | |
| SCHEMBL6170996 | 0.85 | CYP3A4 (0.50) | ALDH1A1RXFP1MEN1KMT2AGAA | |
| SCHEMBL6173613 | 0.84 | KIF11 (0.37) | ALDH1A1RXFP1MEN1KMT2AGAA | |
| SCHEMBL6177570 | 0.83 | ALDH1A1 (0.40) | ALDH1A1RXFP1MEN1KMT2AGAA | |
| SCHEMBL6175398 | 0.83 | GRM5 (0.43) | ALDH1A1MEN1KMT2AGAACYP2C9 | |
| SCHEMBL6172432 | 0.82 | ALDH1A1 (0.38) | ALDH1A1RXFP1MEN1KMT2AGAA | |
| SCHEMBL6172433 | 0.82 | GAA (0.38) | RXFP1MEN1KMT2AGAAPOLB | |
| SCHEMBL6174137 | 0.82 | CYP2C9 (0.36) | ALDH1A1RXFP1MEN1KMT2AGAA | |
| SCHEMBL6172506 | 0.81 | NAMPT (0.40) | ALDH1A1RXFP1GAACYP2C9CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |