Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 4/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | IGF1R | P08069 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6173386 | 0.92 | ALDH1A1 (0.41) | ALDH1A1GAACYP3A4CYP2C9CYP2C19 | |
| SCHEMBL6173479 | 0.87 | ALDH1A1 (0.44) | ALDH1A1GAACYP3A4CYP2C9CYP2C19 | |
| SCHEMBL6173613 | 0.85 | KIF11 (0.37) | ALDH1A1GAACYP3A4CYP2C9CYP2C19 | |
| SCHEMBL6175647 | 0.84 | ALDH1A1 (0.38) | ALDH1A1GAACYP3A4CYP2C9CYP2C19 | |
| SCHEMBL6172506 | 0.84 | NAMPT (0.40) | ALDH1A1GAACYP3A4CYP2C9CYP2C19 | |
| SCHEMBL6171051 | 0.84 | NAMPT (0.48) | CYP2C9NAMPT | |
| SCHEMBL6173219 | 0.83 | ALDH1A1 (0.38) | ALDH1A1GAACYP3A4CYP2C9CYP2C19 | |
| SCHEMBL6172022 | 0.83 | KMT2A (0.36) | ALDH1A1GAACYP3A4CYP2C9CYP2C19 | |
| SCHEMBL6170996 | 0.83 | CYP3A4 (0.50) | ALDH1A1GAACYP3A4CYP2C9CYP2C19 | |
| SCHEMBL6172103 | 0.83 | RXFP1 (0.42) | ALDH1A1GAACYP3A4CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |