Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 13/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 7/20 | 0.36 |
| ▸ | IGF1R | P08069 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | MAT2A | P31153 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA5A | P35218 | 1/20 | 0.32 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6177752 | 0.91 | IGF1R (0.37) | LMNAPTGS2PTGS1IGF1R | |
| SCHEMBL6173805 | 0.90 | IGF1R (0.36) | LMNAPTGS2PTGS1IGF1R | |
| SCHEMBL6174756 | 0.88 | MAT2A (0.43) | LMNAKDM4EMAT2AMAPT | |
| SCHEMBL6174486 | 0.86 | IGF1R (0.38) | LMNAIGF1RSMN1; SMN2MAT2A | |
| SCHEMBL6174200 | 0.85 | IGF1R (0.40) | LMNAIGF1RMAT2A | |
| SCHEMBL6177664 | 0.84 | IGF1R (0.37) | LMNAPTGS2PTGS1IGF1RKMT2A | |
| SCHEMBL6176337 | 0.83 | NPC1 (0.39) | LMNAKDM4EALDH1A1TP53KMT2A | |
| SCHEMBL6173577 | 0.82 | IGF1R (0.39) | LMNAIGF1RALDH1A1SMN1; SMN2 | |
| SCHEMBL6175008 | 0.82 | IGF1R (0.39) | LMNAIGF1RSMN1; SMN2 | |
| SCHEMBL6170257 | 0.81 | IGF1R (0.39) | LMNAPTGS2PTGS1IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |