Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 2/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.31 |
| ▸ | KMO | O15229 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6173805 | 0.91 | IGF1R (0.36) | IGF1RPTGS2PTGS1LMNAMDM2 | |
| SCHEMBL6177752 | 0.86 | IGF1R (0.37) | IGF1RPTGS2PTGS1LMNA | |
| SCHEMBL6174788 | 0.86 | LMNA (0.38) | LMNA | |
| SCHEMBL6170257 | 0.86 | IGF1R (0.39) | IGF1RPTGS2PTGS1LMNAMAPKAPK2 | |
| SCHEMBL6173224 | 0.84 | LMNA (0.36) | IGF1RPTGS2PTGS1LMNAKMT2A | |
| SCHEMBL6175133 | 0.84 | GRM5 (0.43) | — | |
| SCHEMBL6173577 | 0.81 | IGF1R (0.39) | IGF1RLMNA | |
| SCHEMBL6175008 | 0.81 | IGF1R (0.39) | IGF1RLMNA | |
| SCHEMBL6172120 | 0.81 | KDM4E (0.35) | IGF1RPTGS2PTGS1LMNA | |
| SCHEMBL6174119 | 0.80 | PTGS2 (0.37) | IGF1RPTGS2PTGS1MAPKAPK2PDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |