Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAT2A | P31153 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | KDM5A | P29375 | 1/20 | 0.35 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.35 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.34 |
| ▸ | ATP1A1 | P05023 | 1/20 | 0.34 |
| ▸ | ATP1B1 | P05026 | 1/20 | 0.34 |
| ▸ | ATP1A3 | P13637 | 1/20 | 0.34 |
| ▸ | ATP1B2 | P14415 | 1/20 | 0.34 |
| ▸ | ATP1A2 | P50993 | 1/20 | 0.34 |
| ▸ | ATP1B3 | P54709 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6171105 | 0.93 | LMNA (0.39) | MAT2ALMNASCN10AL3MBTL1POLB | |
| SCHEMBL6174848 | 0.92 | LMNA (0.46) | MAT2ALMNASCN10AL3MBTL1POLB | |
| SCHEMBL6174200 | 0.89 | IGF1R (0.40) | MAT2ALMNAPDE2AFPR2 | |
| SCHEMBL6173224 | 0.88 | LMNA (0.36) | MAT2ALMNAKDM4EMAPT | |
| SCHEMBL6174788 | 0.86 | LMNA (0.38) | LMNAL3MBTL1POLBMCHR1NPBWR1 | |
| SCHEMBL6175578 | 0.84 | LMNA (0.42) | LMNAL3MBTL1POLBATP1A1ATP1B1 | |
| SCHEMBL6173438 | 0.84 | LMNA (0.42) | LMNAL3MBTL1POLBKDM4EGAA | |
| SCHEMBL6176756 | 0.84 | LMNA (0.42) | LMNAL3MBTL1POLBATP1A1ATP1B1 | |
| SCHEMBL6174656 | 0.83 | LMNA (0.41) | LMNAL3MBTL1POLBATP1A1ATP1B1 | |
| SCHEMBL6175660 | 0.82 | LMNA (0.40) | LMNAL3MBTL1POLBMCHR1NPBWR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |